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Flights from Buffalo to Panama City

Find cheap airlines flights from Buffalo to Panama City

You can choose from 1 airlines that fly from Buffalo to Panama City, including American Airlines, Delta Air Lines has lowest fares on this route.
American Airlines logo American Airlines
Airlines are determined based on actual purchased flight tickets from Buffalo to Panama City according to previous 12 months data from Trip.com.

Find flight deals from Buffalo to Panama City for the next 3 months. Book one way flights from $169 or round trip flights from $317.

      • BUF 6:00 AM
        5h 15m
        1 stop
        ECP 10:15 AM
        Buffalo - Panama City | Tue, Apr 28 | Delta Air Lines
        ECP 8:21 AM
        6h 32m
        1 stop
        BUF 3:53 PM
        Panama City - Buffalo | Tue, May 5 | Delta Air Lines
        $317 $592
        46% off
        46% off
        $592 $317
      • BUF 7:40 PM
        4h 32m
        1 stop
        ECP 11:12 PM
        Buffalo - Panama City | Fri, May 1 | Delta Air Lines
        ECP 5:29 PM
        5h 30m
        1 stop
        BUF 11:59 PM
        Panama City - Buffalo | Sat, May 9 | Delta Air Lines
        $363 $592
        39% off
        39% off
        $592 $363
      • BUF 4:59 PM
        7h 13m
        1 stop
        ECP 11:12 PM
        Buffalo - Panama City | Wed, Apr 22 | Delta Air Lines
        ECP 8:21 AM
        6h 32m
        1 stop
        BUF 3:53 PM
        Panama City - Buffalo | Wed, Apr 29 | Delta Air Lines
        $365 $592
        38% off
        38% off
        $592 $365
      • BUF 7:39 PM
        4h 22m
        1 stop
        ECP 11:01 PM
        Buffalo - Panama City | Wed, May 20 | Delta Air Lines
        ECP 6:00 AM
        4h 23m
        1 stop
        BUF 11:23 AM
        Panama City - Buffalo | Sun, May 24 | Delta Air Lines
        $389
        34% off
        $592 $389
      • BUF 6:00 AM
        5h 58m
        1 stop
        ECP 10:58 AM
        Buffalo - Panama City | Tue, Apr 28 | American Airlines
        ECP 11:43 AM
        5h 20m
        1 stop
        BUF 6:03 PM
        Panama City - Buffalo | Tue, May 5 | American Airlines
        $391
        34% off
        $592 $391
      • BUF 7:39 PM
        4h 49m
        1 stop
        ECP 11:28 PM
        Buffalo - Panama City | Thu, Jun 4 | Delta Air Lines
        ECP 7:41 AM
        7h 9m
        1 stop
        BUF 3:50 PM
        Panama City - Buffalo | Fri, Jun 5 | Delta Air Lines
        $392
        34% off
        $592 $392
      • BUF 7:27 PM
        5h 17m
        1 stop
        ECP 11:44 PM
        Buffalo - Panama City | Sun, Jun 7 | Delta Air Lines
        ECP 6:41 PM
        4h 18m
        1 stop
        BUF 11:59 PM
        Panama City - Buffalo | Mon, Jun 8 | Delta Air Lines
        $392
        34% off
        $592 $392
      • BUF 7:00 AM
        7h 23m
        1 stop
        ECP 1:23 PM
        Buffalo - Panama City | Tue, Apr 28 | United Airlines
        ECP 2:14 PM
        5h 47m
        1 stop
        BUF 9:01 PM
        Panama City - Buffalo | Tue, May 5 | United Airlines
        $396
        33% off
        $592 $396
      • BUF 4:59 PM
        5h 23m
        1 stop
        ECP 9:22 PM
        Buffalo - Panama City | Mon, Apr 27 | Delta Air Lines
        ECP 5:49 AM
        4h 12m
        1 stop
        BUF 11:01 AM
        Panama City - Buffalo | Mon, May 4 | Delta Air Lines
        $432
        27% off
        $592 $432
      • BUF 7:28 PM
        5h 18m
        1 stop
        ECP 11:46 PM
        Buffalo - Panama City | Fri, May 1 | American Airlines
        ECP 10:48 AM
        6h 50m
        1 stop
        BUF 6:38 PM
        Panama City - Buffalo | Sat, May 9 | American Airlines
        $438
        26% off
        $592 $438
      • BUF 1:00 PM
        17h 25m
        1 stop
        ECP Invalid Date
        Buffalo - Panama City | Sun, Apr 19 | Normal Airline
        ECP 3:00 PM
        6h
        Nonstop
        BUF 4:00 PM
        Panama City - Buffalo | Tue, Apr 21 | Normal Airline
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      • BUF 6:04 AM
        6h 35m
        1 stop
        ECP 11:39 AM
        Buffalo - Panama City | Wed, May 13 | Delta Air Lines
        $169 $328
        48% off
        48% off
        $328 $169
      • BUF 6:15 AM
        5h 38m
        1 stop
        ECP 10:53 AM
        Buffalo - Panama City | Tue, May 12 | Delta Air Lines
        $185 $328
        44% off
        44% off
        $328 $185
      • BUF 7:39 PM
        4h 49m
        1 stop
        ECP 11:28 PM
        Buffalo - Panama City | Mon, May 11 | Delta Air Lines
        $203 $328
        38% off
        38% off
        $328 $203
      • BUF 7:00 AM
        7h 23m
        1 stop
        ECP 1:23 PM
        Buffalo - Panama City | Tue, Apr 21 | United Airlines
        $211
        36% off
        $328 $211
      • BUF 7:00 AM
        7h 12m
        1 stop
        ECP 1:12 PM
        Buffalo - Panama City | Tue, May 12 | United Airlines
        $219
        33% off
        $328 $219
      • BUF 7:00 AM
        7h 12m
        1 stop
        ECP 1:12 PM
        Buffalo - Panama City | Mon, May 11 | United Airlines
        $223
        32% off
        $328 $223
      • BUF 7:00 AM
        7h 18m
        1 stop
        ECP 1:18 PM
        Buffalo - Panama City | Sun, May 10 | United Airlines
        $234
        28% off
        $328 $234
      • BUF 6:15 AM
        5h 39m
        1 stop
        ECP 10:54 AM
        Buffalo - Panama City | Sun, May 10 | Delta Air Lines
        $235
        28% off
        $328 $235
      • BUF 7:00 AM
        7h 18m
        1 stop
        ECP 1:18 PM
        Buffalo - Panama City | Mon, May 18 | United Airlines
        $240
        27% off
        $328 $240
      • BUF 7:00 AM
        7h 18m
        1 stop
        ECP 1:18 PM
        Buffalo - Panama City | Fri, May 15 | United Airlines
        $242
        26% off
        $328 $242
      • BUF 1:00 PM
        17h 25m
        1 stop
        ECP Invalid Date
        Buffalo - Panama City | Sun, Apr 19 | Normal Airline
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Displayed flight fares from Buffalo to Panama City are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flight Info | Buffalo to Panama City

The distance between Buffalo and Panama City is approximately 1,547.36 km. Based on Trip.com's data travel demand peaks in December. The off-season for travel is October.

Cheapest one-way flight price$169
Cheapest round-trip ticket price$317
Off-season for travelOctober
Peak season for travelDecember
Flight distance1,547.36 km
Popular airlineAmerican Airlines
Flight statistics for the Buffalo–Panama City route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Buffalo to Panama City (BUF-ECP)?

    Based on Trip.com data, Delta Air Lines offers one-way fares as low as $169 on Cheapest nonstop routes (e.g. BUF to ECP on Wed, May 13), while Delta Air Lines offers Cheapest nonstop round-trips from $317 departing on Tue, Apr 28 and returning on Tue, May 5.
  • At the moment, several airlines serve connecting flights from Buffalo to Panama City, including: American Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Buffalo to Panama City is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Buffalo to Panama City, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, May 13, with one-way flights priced at just $169.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Delta Air Lines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Panama City travel is around December.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Buffalo to Panama City is October, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Buffalo to Panama City on April 17, 2026 with Delta Air Lines, with prices starting at $200.
  • You can land at any one of the following hubs in Panama City, with Buffalo Niagara International Airport to Northwest Florida Beaches International Airport (BUF-ECP) is by far the most common option on this route: Northwest Florida Beaches International Airport (ECP).
  • The time difference between Panama City and Buffalo is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

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Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.