Cheap Flights from Chicago to Knoxville from $125

Frequently Asked Questions

• What are the cheapest flights from Chicago to Knoxville (CHI-TYS)?

  Based on Trip.com data, Delta Air Lines offers one-way fares as low as $125 on Cheapest nonstop routes (e.g. MDW to TYS on Wed, May 20), while United Airlines offers Cheapest nonstop round-trips from $245 departing on Fri, May 8 and returning on Mon, May 11.

• Which airlines offer direct flights from Chicago to Knoxville?

  At the moment, you can catch a nonstop flight from Chicago to Knoxville with the following airlines, including: American Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long does it take to fly from Chicago (CHI) to Knoxville (TYS) and what is the distance?

  It takes around 1 hour 49 minutes to fly from Chicago (CHI) to Knoxville (TYS).

• When is the best time to book flights from Chicago to Knoxville?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Chicago to Knoxville is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Chicago to Knoxville?

  Based on Trip.com data in the past 4 weeks, there is 43 flight per week flying from Chicago to Knoxville. You can check the weekly schedule for popular airlines on this route below: American Airlines: S/M/T/W/T/F/S -- AA5222 (08:55)

• How can I find the best deals on flights from Chicago to Knoxville?

  To find best deals on flights from Chicago to Knoxville, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, May 20, with one-way flights priced at just $125.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Knoxville travel is around January.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Chicago (CHI) to Knoxville (TYS) the cheapest?

  The cheapest months to fly from Chicago to Knoxville is September, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Chicago to Knoxville on?

  After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Chicago to Knoxville on April 20, 2026 with Delta Air Lines, with prices starting at $201.

• Which airports can I fly to for Knoxville from Chicago?

  You can land at any one of the following hubs in Knoxville, with Chicago Midway International Airport to Mcghee Tyson Airport (MDW-TYS) is by far the most common option on this route: Mcghee Tyson Airport (TYS).

• Is there any time difference between Chicago and Knoxville?

  The time difference between Knoxville and Chicago is 1h.

• How do I change or cancel my ticket from Chicago to Knoxville?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.