Trip.com
>
Flights
>
Flights to United States
>
Flights to Panama City
Hotels in Panama City
>
Flights from Columbus to Panama City

Find cheap airlines flights from Columbus to Panama City

You can choose from 1 airlines that fly from Columbus to Panama City, including Delta Air Lines, Delta Air Lines has lowest fares on this route.
Delta Air Lines logo Delta Air Lines
Airlines are determined based on actual purchased flight tickets from Columbus to Panama City according to previous 12 months data from Trip.com.

Find flight deals from Columbus to Panama City for the next 3 months. Book one way flights from $134 or round trip flights from $256.

      • CMH 7:59 PM
        4h 29m
        1 stop
        ECP 11:28 PM
        Columbus - Panama City | Sun, May 17 | Delta Air Lines
        ECP 1:50 PM
        6h 43m
        1 stop
        CMH 9:33 PM
        Panama City - Columbus | Sat, May 23 | Delta Air Lines
        $256 $394
        35% off
        35% off
        $394 $256
      • CMH 6:00 AM
        3h 35m
        1 stop
        ECP 8:35 AM
        Columbus - Panama City | Wed, Apr 22 | Delta Air Lines
        ECP 1:33 PM
        3h 56m
        1 stop
        CMH 6:29 PM
        Panama City - Columbus | Sat, Apr 25 | Delta Air Lines
        $297 $394
        25% off
        25% off
        $394 $297
      • CMH 7:59 PM
        4h 29m
        1 stop
        ECP 11:28 PM
        Columbus - Panama City | Mon, May 18 | Delta Air Lines
        ECP 11:39 AM
        6h 25m
        1 stop
        CMH 7:04 PM
        Panama City - Columbus | Mon, May 25 | Delta Air Lines
        $315 $394
        20% off
        20% off
        $394 $315
      • CMH 6:00 AM
        13h 43m
        1 stop
        ECP 6:43 PM
        Columbus - Panama City | Tue, Jun 16 | Delta Air Lines
        ECP 6:00 AM
        10h 21m
        1 stop
        CMH 5:21 PM
        Panama City - Columbus | Mon, Jun 22 | Delta Air Lines
        $325
        18% off
        $394 $325
      • CMH 3:00 PM
        5h 36m
        1 stop
        ECP 7:36 PM
        Columbus - Panama City | Mon, May 4 | Delta Air Lines
        ECP 6:46 PM
        4h 57m
        1 stop
        CMH 12:43 AM
        Panama City - Columbus | Thu, May 7 | Delta Air Lines
        $326
        17% off
        $394 $326
      • CMH 6:00 AM
        3h 30m
        1 stop
        ECP 8:30 AM
        Columbus - Panama City | Wed, May 13 | Delta Air Lines
        ECP 6:00 AM
        6h 34m
        1 stop
        CMH 1:34 PM
        Panama City - Columbus | Tue, May 19 | Delta Air Lines
        $329
        16% off
        $394 $329
      • CMH 6:00 AM
        3h 35m
        1 stop
        ECP 8:35 AM
        Columbus - Panama City | Wed, Apr 29 | Delta Air Lines
        ECP 7:05 AM
        5h 49m
        1 stop
        CMH 1:54 PM
        Panama City - Columbus | Mon, May 4 | Delta Air Lines
        $331
        16% off
        $394 $331
      • CMH 6:00 AM
        3h 35m
        1 stop
        ECP 8:35 AM
        Columbus - Panama City | Tue, Apr 28 | Delta Air Lines
        ECP 6:46 PM
        4h 57m
        1 stop
        CMH 12:43 AM
        Panama City - Columbus | Mon, May 4 | Delta Air Lines
        $331
        16% off
        $394 $331
      • CMH 6:00 AM
        3h 35m
        1 stop
        ECP 8:35 AM
        Columbus - Panama City | Tue, May 5 | Delta Air Lines
        ECP 2:50 PM
        5h 43m
        1 stop
        CMH 9:33 PM
        Panama City - Columbus | Sun, May 10 | Delta Air Lines
        $331
        16% off
        $394 $331
      • CMH 6:00 AM
        3h 30m
        1 stop
        ECP 8:30 AM
        Columbus - Panama City | Fri, Jun 5 | Delta Air Lines
        ECP 6:00 AM
        6h 49m
        1 stop
        CMH 1:49 PM
        Panama City - Columbus | Sun, Jun 7 | Delta Air Lines
        $342
        13% off
        $394 $342
      • CMH 1:00 PM
        17h 25m
        1 stop
        ECP Invalid Date
        Columbus - Panama City | Mon, Apr 20 | Normal Airline
        ECP 3:00 PM
        6h
        Nonstop
        CMH 4:00 PM
        Panama City - Columbus | Wed, Apr 22 | Normal Airline
        Find more flights
        Find more flights
      • CMH 7:05 AM
        6h 45m
        1 stop
        ECP 12:50 PM
        Columbus - Panama City | Wed, May 20 | Delta Air Lines
        $134 $300
        55% off
        55% off
        $300 $134
      • CMH 8:35 AM
        5h 10m
        1 stop
        ECP 12:45 PM
        Columbus - Panama City | Mon, Apr 20 | Delta Air Lines
        $162 $300
        46% off
        46% off
        $300 $162
      • CMH 6:00 AM
        7h 19m
        1 stop
        ECP 12:19 PM
        Columbus - Panama City | Thu, Apr 23 | Delta Air Lines
        $167 $300
        44% off
        44% off
        $300 $167
      • CMH 4:54 PM
        6h 11m
        1 stop
        ECP 10:05 PM
        Columbus - Panama City | Wed, May 20 | United Airlines
        $170
        43% off
        $300 $170
      • CMH 5:05 AM
        6h 53m
        1 stop
        ECP 10:58 AM
        Columbus - Panama City | Wed, May 20 | American Airlines
        $176
        41% off
        $300 $176
      • CMH 6:44 PM
        5h 7m
        1 stop
        ECP 10:51 PM
        Columbus - Panama City | Sun, Jun 14 | Delta Air Lines
        $177
        41% off
        $300 $177
      • CMH 3:50 PM
        4h 46m
        1 stop
        ECP 7:36 PM
        Columbus - Panama City | Mon, Jun 15 | Delta Air Lines
        $177
        41% off
        $300 $177
      • CMH 6:00 AM
        5h 54m
        1 stop
        ECP 10:54 AM
        Columbus - Panama City | Mon, Jun 1 | Delta Air Lines
        $179
        40% off
        $300 $179
      • CMH 6:00 AM
        5h 28m
        1 stop
        ECP 10:28 AM
        Columbus - Panama City | Mon, Jun 1 | American Airlines
        $184
        39% off
        $300 $184
      • CMH 5:01 PM
        5h 58m
        1 stop
        ECP 9:59 PM
        Columbus - Panama City | Mon, Jun 1 | United Airlines
        $196
        35% off
        $300 $196
      • CMH 1:00 PM
        17h 25m
        1 stop
        ECP Invalid Date
        Columbus - Panama City | Mon, Apr 20 | Normal Airline
        Find more flights
        Find more flights

Displayed flight fares from Columbus to Panama City are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flight Info | Columbus to Panama City

The distance between Columbus and Panama City is approximately 1,121.32 km. Based on Trip.com's data travel demand peaks in July. The off-season for travel is August.

Cheapest one-way flight price$134
Cheapest round-trip ticket price$256
Off-season for travelAugust
Peak season for travelJuly
Flight distance1,121.32 km
Popular airlineDelta Air Lines
Flight statistics for the Columbus–Panama City route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Columbus to Panama City (CMH-ECP)?

    Based on Trip.com data, Delta Air Lines offers one-way fares as low as $134 on Cheapest nonstop routes (e.g. CMH to ECP on Wed, May 20), while Delta Air Lines offers Cheapest nonstop round-trips from $256 departing on Sun, May 17 and returning on Sat, May 23.
  • At the moment, several airlines serve connecting flights from Columbus to Panama City, including: Delta Air Lines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Columbus to Panama City is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Columbus to Panama City, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, May 20, with one-way flights priced at just $134.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Delta Air Lines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Panama City travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Columbus to Panama City is August, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Columbus to Panama City on April 19, 2026 with Delta Air Lines, with prices starting at $297.
  • You can land at any one of the following hubs in Panama City, with John Glenn Columbus International Airport to Northwest Florida Beaches International Airport (CMH-ECP) is by far the most common option on this route: Northwest Florida Beaches International Airport (ECP).
  • The time difference between Panama City and Columbus is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Explore More Popular Flights

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.