Cheap Flights from Denver to Panama City from $348

Frequently Asked Questions

• What are the cheapest flights from Denver to Panama City (DEN-PTY)?

  Based on Trip.com data, Frontier Airlines offers one-way fares as low as $348 on Cheapest nonstop routes (e.g. DEN to PTY on Thu, Oct 1), while United Airlines offers Cheapest nonstop round-trips from $536 departing on Mon, Sep 7 and returning on Sun, Sep 13.

• Which airlines offer direct flights from Denver to Panama City?

  At the moment, you can catch a nonstop flight from Denver to Panama City with the following airlines, including: Copa Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long does it take to fly from Denver (DEN) to Panama City (PTY) and what is the distance?

  It takes around 5 hours 35 minutes to fly from Denver (DEN) to Panama City (PTY).

• When is the best time to book flights from Denver to Panama City?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Denver to Panama City is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Denver to Panama City?

  Based on Trip.com data in the past 4 weeks, there is 5 flight per week flying from Denver to Panama City. You can check the weekly schedule for popular airlines on this route below: Copa Airlines: -/-/T/W/T/F/S -- CM477 (23:05)

• How can I find the best deals on flights from Denver to Panama City?

  To find best deals on flights from Denver to Panama City, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Thu, Oct 1, with one-way flights priced at just $348.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Copa Airlines.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Panama City travel is around January.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Denver (DEN) to Panama City (PTY) the cheapest?

  The cheapest months to fly from Denver to Panama City is November, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Denver to Panama City on?

  After crunching the numbers on our August flight calendar, it's currently cheapest to fly from Denver to Panama City on August 20, 2026 with United Airlines, with prices starting at $527.

• Which airports can I fly to for Panama City from Denver?

  You can land at any one of the following hubs in Panama City, with Denver International Airport to Tocumen International Airport (DEN-PTY) is by far the most common option on this route: Tocumen International Airport (PTY) Marcos A. Gelabert International Airport (PAC).

• Is there any time difference between Denver and Panama City?

  The time difference between Panama City and Denver is 2h.

• How do I change or cancel my ticket from Denver to Panama City?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from Denver to Panama City?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Denver to Panama City is $617. Fares vary by travel date, airline and availability.

• What is the average cost of a round-trip flight from Denver to Panama City?

  Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Denver to Panama City is $647. The final price depends on the outbound and return dates, airline and fare conditions.

• How do I book flights from Denver to Panama City on Trip.com?

  Enter Denver and Panama City, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.