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Flights from Jacksonville to St. Louis

What to know about flights from Jacksonville to St. Louis?

The distance between Jacksonville and St. Louis is approximately 1,200.88 km. It takes around 2 hours 40 minutes on average to fly from Jacksonville to St. Louis. Based on Trip.com's data, travel demand peaks in July.

Cheapest one-way
$46
Frontier Airlines Frontier Airlines JAX-STL 24h 36m · 1 stop Wed, Nov 18
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Cheapest round-trip
$226
Delta Air Lines Delta Air Lines JAX-STL 6h 17m · 2 stops Sat, Oct 31 - Wed, Nov 4
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Recommended airlines
Frontier Airlines Frontier AirlinesCheapest· From $46 American Airlines American AirlinesMost booked
When to travel
October
Cheapest
July
Peak season for travel
Route details
1,200.88 km
Flight distance
2h 40m
Average flight time

Explore the cheapest one-way and round-trip flights from Jacksonville to St. Louis over the next 90 days, with one-way fares from $46 and round-trip from $226. Based on Trip.com's latest 7-day flight data.

    • JAX 12:58 PM
      6h 17m
      1 stop
      STL 6:15 PM
      Jacksonville - St. Louis | Sat, Oct 31 | Delta Air Lines
      STL 5:38 PM
      5h 18m
      1 stop
      JAX 11:56 PM
      St. Louis - Jacksonville | Wed, Nov 4 | Delta Air Lines
      $226 $342
      34% off
      34% off
      $342 $226
    • JAX 5:05 AM
      5h 4m
      1 stop
      STL 9:09 AM
      Jacksonville - St. Louis | Sun, Nov 1 | Delta Air Lines
      STL 2:25 PM
      6h 22m
      1 stop
      JAX 9:47 PM
      St. Louis - Jacksonville | Wed, Nov 4 | Delta Air Lines
      $235 $342
      31% off
      31% off
      $342 $235
    • JAX 6:14 AM
      5h 39m
      1 stop
      STL 10:53 AM
      Jacksonville - St. Louis | Mon, Nov 9 | American Airlines
      STL 6:00 AM
      4h 42m
      1 stop
      JAX 11:42 AM
      St. Louis - Jacksonville | Wed, Nov 11 | American Airlines
      $240 $342
      30% off
      30% off
      $342 $240
    • JAX 9:45 AM
      4h 54m
      1 stop
      STL 1:39 PM
      Jacksonville - St. Louis | Fri, Nov 6 | Delta Air Lines
      STL 7:00 AM
      3h 53m
      1 stop
      JAX 11:53 AM
      St. Louis - Jacksonville | Mon, Nov 9 | Delta Air Lines
      $262
      23% off
      $342 $262
    • JAX 6:12 PM
      6h 47m
      1 stop
      STL 11:59 PM
      Jacksonville - St. Louis | Wed, Oct 21 | American Airlines
      STL 6:07 PM
      4h 52m
      1 stop
      JAX 11:59 PM
      St. Louis - Jacksonville | Sun, Oct 25 | American Airlines
      $288
      16% off
      $342 $288
    • JAX 5:00 AM
      4h 13m
      1 stop
      STL 8:13 AM
      Jacksonville - St. Louis | Sat, Nov 21 | American Airlines
      STL 5:00 AM
      6h 43m
      1 stop
      JAX 12:43 PM
      St. Louis - Jacksonville | Mon, Nov 23 | American Airlines
      $291
      15% off
      $342 $291
    • JAX 5:00 AM
      4h 13m
      1 stop
      STL 8:13 AM
      Jacksonville - St. Louis | Thu, Dec 3 | American Airlines
      STL 8:10 AM
      4h 46m
      1 stop
      JAX 1:56 PM
      St. Louis - Jacksonville | Fri, Dec 11 | American Airlines
      $291
      15% off
      $342 $291
    • JAX 8:35 AM
      3h 54m
      1 stop
      STL 11:29 AM
      Jacksonville - St. Louis | Fri, Dec 4 | Delta Air Lines
      STL 7:18 PM
      3h 51m
      1 stop
      JAX 12:09 AM
      St. Louis - Jacksonville | Sat, Dec 5 | Delta Air Lines
      $293
      14% off
      $342 $293
    • JAX 5:08 AM
      4h 29m
      1 stop
      STL 8:37 AM
      Jacksonville - St. Louis | Sat, Oct 24 | American Airlines
      STL 6:32 AM
      5h 29m
      1 stop
      JAX 1:01 PM
      St. Louis - Jacksonville | Wed, Oct 28 | American Airlines
      $293
      14% off
      $342 $293
    • JAX 1:00 PM
      17h 25m
      1 stop
      STL 2:00 PM
      Jacksonville - St. Louis | Tue, Oct 20 | Normal Airline
      STL 3:00 PM
      6h
      Nonstop
      JAX 4:00 PM
      St. Louis - Jacksonville | Thu, Oct 22 | Normal Airline
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    • Cheapest
      JAX 7:03 PM
      24h 36m
      1 stop
      STL 6:39 PM
      Jacksonville - St. Louis | Wed, Nov 18 | Frontier Airlines
      $46 $288
      84% off
      84% off
      $288 $46
    • JAX 7:03 PM
      23h 37m
      1 stop
      STL 5:40 PM
      Jacksonville - St. Louis | Sun, Nov 1 | Frontier Airlines
      $54 $288
      81% off
      81% off
      $288 $54
    • JAX 7:03 PM
      23h 37m
      1 stop
      STL 5:40 PM
      Jacksonville - St. Louis | Thu, Oct 29 | Frontier Airlines
      $57 $288
      80% off
      80% off
      $288 $57
    • JAX 7:03 PM
      23h 39m
      1 stop
      STL 5:42 PM
      Jacksonville - St. Louis | Thu, Nov 12 | Frontier Airlines
      $60
      79% off
      $288 $60
    • JAX 7:03 PM
      23h 39m
      1 stop
      STL 5:42 PM
      Jacksonville - St. Louis | Sun, Nov 8 | Frontier Airlines
      $73
      75% off
      $288 $73
    • JAX 7:03 PM
      23h 37m
      1 stop
      STL 5:40 PM
      Jacksonville - St. Louis | Sun, Nov 15 | Frontier Airlines
      $73
      75% off
      $288 $73
    • JAX 6:20 PM
      24h 20m
      1 stop
      STL 5:40 PM
      Jacksonville - St. Louis | Thu, Oct 22 | Frontier Airlines
      $74
      74% off
      $288 $74
    • JAX 7:46 PM
      22h 54m
      1 stop
      STL 5:40 PM
      Jacksonville - St. Louis | Tue, Oct 20 | Frontier Airlines
      $77
      73% off
      $288 $77
    • JAX 7:03 PM
      23h 39m
      1 stop
      STL 5:42 PM
      Jacksonville - St. Louis | Thu, Nov 5 | Frontier Airlines
      $81
      72% off
      $288 $81
    • JAX 1:00 PM
      17h 25m
      1 stop
      STL 2:00 PM
      Jacksonville - St. Louis | Tue, Oct 20 | Normal Airline
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Displayed flight fares from Jacksonville to St. Louis are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flight.News
Flights from Jacksonville to St. Louis operate an average of 2 times per day over the past 7 days, with a 72.7% on-time departure rate and a 100.0% on-time arrival rate.

Which airlines are the most popular for Jacksonville to St. Louis flights?

You can choose from 1 airlines that fly from Jacksonville to St. Louis, including American Airlines, Frontier Airlines has lowest fares on this route.
American Airlines logo American Airlines
Airlines are determined based on actual purchased flight tickets from Jacksonville to St. Louis according to previous 12 months data from Trip.com.

Frequently Asked Questions

  • What are the cheapest flights from Jacksonville to St. Louis (JAX-STL)?

    Based on Trip.com data, Frontier Airlines offers one-way fares as low as $46 on Cheapest nonstop routes (e.g. JAX to STL on Wed, Nov 18), while Delta Air Lines offers Cheapest nonstop round-trips from $226 departing on Sat, Oct 31 and returning on Wed, Nov 4.
  • At the moment, several airlines serve connecting flights from Jacksonville to St. Louis, including: American Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • It takes around 2 hours 40 minutes to fly from Jacksonville (JAX) to St. Louis (STL).
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Jacksonville to St. Louis is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Jacksonville to St. Louis, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Nov 18, with one-way flights priced at just $46.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Frontier Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for St. Louis travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Jacksonville to St. Louis is October, when demand for travel is lower.
  • After crunching the numbers on our October flight calendar, it's currently cheapest to fly from Jacksonville to St. Louis on October 29, 2026 with Delta Air Lines, with prices starting at $226.
  • You can arrive at any of the following airports in St. Louis: St. Louis Lambert International Airport (STL), and St. Louis Downtown Airport (CPS). Flights from Jacksonville International Airport to St. Louis Lambert International Airport (JAX-STL) are by far the most popular option for this route.
  • The time difference between St. Louis and Jacksonville is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.
  • Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Jacksonville to St. Louis is $210. Fares vary by travel date, airline and availability.
  • Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Jacksonville to St. Louis is $429. The final price depends on the outbound and return dates, airline and fare conditions.
  • Enter Jacksonville and St. Louis, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.