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Flights from Knoxville to Charlotte

Book direct flights from Knoxville to Charlotte: One way flights from $292, round trip flights from $551. Find flight deals for the next 3 months below.

      • Cheapest nonstop
        TYS 11:01 AM
        1h 25m
        Nonstop
        CLT 12:26 PM
        Knoxville - Charlotte | Sun, May 24 | American Airlines
        CLT 7:16 AM
        1h 18m
        Nonstop
        TYS 8:34 AM
        Charlotte - Knoxville | Tue, May 26 | American Airlines
        $551 $672
        18% off
        18% off
        $672 $551
      • TYS 6:07 PM
        1h 28m
        Nonstop
        CLT 7:35 PM
        Knoxville - Charlotte | Sun, Jun 21 | American Airlines
        CLT 6:14 PM
        1h 19m
        Nonstop
        TYS 7:33 PM
        Charlotte - Knoxville | Mon, Jun 22 | American Airlines
        $551 $672
        18% off
        18% off
        $672 $551
      • TYS 5:40 AM
        3h 16m
        1 stop
        CLT 8:56 AM
        Knoxville - Charlotte | Sat, May 30 | Delta Air Lines
        CLT 9:41 AM
        3h 29m
        1 stop
        TYS 1:10 PM
        Charlotte - Knoxville | Wed, Jun 3 | Delta Air Lines
        $177 $672
        74% off
        74% off
        $672 $177
      • TYS 11:55 AM
        4h 23m
        1 stop
        CLT 4:18 PM
        Knoxville - Charlotte | Wed, Jun 17 | Delta Air Lines
        CLT 8:01 AM
        5h 18m
        1 stop
        TYS 1:19 PM
        Charlotte - Knoxville | Wed, Jun 24 | Delta Air Lines
        $202
        70% off
        $672 $202
      • TYS 7:35 AM
        3h 57m
        1 stop
        CLT 11:32 AM
        Knoxville - Charlotte | Sat, Jun 20 | Delta Air Lines
        CLT 8:01 AM
        5h 18m
        1 stop
        TYS 1:19 PM
        Charlotte - Knoxville | Sat, Jun 27 | Delta Air Lines
        $202
        70% off
        $672 $202
      • TYS 7:35 AM
        3h 57m
        1 stop
        CLT 11:32 AM
        Knoxville - Charlotte | Mon, Jun 22 | Delta Air Lines
        CLT 12:19 PM
        4h 56m
        1 stop
        TYS 5:15 PM
        Charlotte - Knoxville | Mon, Jun 29 | Delta Air Lines
        $202
        70% off
        $672 $202
      • TYS 1:59 PM
        6h 15m
        1 stop
        CLT 8:14 PM
        Knoxville - Charlotte | Tue, Jun 2 | Delta Air Lines
        CLT 5:35 AM
        3h 59m
        1 stop
        TYS 9:34 AM
        Charlotte - Knoxville | Fri, Jun 5 | Delta Air Lines
        $203
        70% off
        $672 $203
      • TYS 11:55 AM
        6h 24m
        1 stop
        CLT 6:19 PM
        Knoxville - Charlotte | Tue, Jun 16 | Delta Air Lines
        CLT 12:19 PM
        4h 56m
        1 stop
        TYS 5:15 PM
        Charlotte - Knoxville | Tue, Jun 23 | Delta Air Lines
        $215
        68% off
        $672 $215
      • TYS 5:40 AM
        3h 13m
        1 stop
        CLT 8:53 AM
        Knoxville - Charlotte | Fri, Jun 19 | Delta Air Lines
        CLT 9:42 AM
        5h 7m
        1 stop
        TYS 2:49 PM
        Charlotte - Knoxville | Fri, Jun 26 | Delta Air Lines
        $386
        43% off
        $672 $386
      • TYS 1:00 PM
        17h 25m
        1 stop
        CLT 2:00 PM
        Knoxville - Charlotte | Fri, May 22 | Normal Airline
        CLT 3:00 PM
        6h
        Nonstop
        TYS 4:00 PM
        Charlotte - Knoxville | Sun, May 24 | Normal Airline
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      • Cheapest nonstop
        TYS 11:01 AM
        1h 25m
        Nonstop
        CLT 12:26 PM
        Knoxville - Charlotte | Mon, May 25 | American Airlines
        $292 $446
        35% off
        35% off
        $446 $292
      • TYS 1:00 PM
        1h 28m
        Nonstop
        CLT 2:28 PM
        Knoxville - Charlotte | Wed, Jun 24 | American Airlines
        $365 $446
        18% off
        18% off
        $446 $365
      • TYS 10:26 AM
        5h 52m
        1 stop
        CLT 4:18 PM
        Knoxville - Charlotte | Wed, Jun 17 | Delta Air Lines
        $64 $446
        86% off
        86% off
        $446 $64
      • TYS 7:46 PM
        4h 13m
        1 stop
        CLT 11:59 PM
        Knoxville - Charlotte | Tue, Jun 16 | Delta Air Lines
        $65
        85% off
        $446 $65
      • TYS 8:35 AM
        5h
        1 stop
        CLT 1:35 PM
        Knoxville - Charlotte | Thu, Jun 18 | Delta Air Lines
        $65
        85% off
        $446 $65
      • TYS 5:40 AM
        3h 13m
        1 stop
        CLT 8:53 AM
        Knoxville - Charlotte | Fri, Jun 19 | Delta Air Lines
        $71
        84% off
        $446 $71
      • TYS 5:40 AM
        5h 52m
        1 stop
        CLT 11:32 AM
        Knoxville - Charlotte | Thu, Jun 11 | Delta Air Lines
        $79
        82% off
        $446 $79
      • TYS 5:40 AM
        3h 16m
        1 stop
        CLT 8:56 AM
        Knoxville - Charlotte | Tue, May 26 | Delta Air Lines
        $105
        76% off
        $446 $105
      • TYS 5:40 AM
        3h 13m
        1 stop
        CLT 8:53 AM
        Knoxville - Charlotte | Sat, Jun 13 | Delta Air Lines
        $111
        75% off
        $446 $111
      • TYS 3:30 PM
        4h 44m
        1 stop
        CLT 8:14 PM
        Knoxville - Charlotte | Mon, Jun 1 | Delta Air Lines
        $163
        63% off
        $446 $163
      • TYS 1:00 PM
        17h 25m
        1 stop
        CLT 2:00 PM
        Knoxville - Charlotte | Fri, May 22 | Normal Airline
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Displayed flight fares from Knoxville to Charlotte are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Frequently Asked Questions

  • What are the cheapest flights from Knoxville to Charlotte (TYS-CLT)?

    Based on Trip.com data, Delta Air Lines offers one-way fares as low as $64 on Cheapest nonstop routes (e.g. TYS to CLT on Wed, Jun 17), while Delta Air Lines offers Cheapest nonstop round-trips from $177 departing on Sat, May 30 and returning on Wed, Jun 3.
  • At the moment, you can catch a nonstop flight from Knoxville to Charlotte with the following airlines, including: American Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes around 1 hour 25 minutes to fly from Knoxville (TYS) to Charlotte (CLT).
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Knoxville to Charlotte is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 53 flight per week flying from Knoxville to Charlotte. You can check the weekly schedule for popular airlines on this route below: American Airlines: S/M/T/W/T/F/S -- AA5208 (09:13) American Airlines: S/M/T/W/T/F/S -- AA5182 (08:29) American Airlines: S/M/T/W/T/F/S -- AA5471 (05:02)
  • To find best deals on flights from Knoxville to Charlotte, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Jun 17, with one-way flights priced at just $64.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Charlotte travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Knoxville to Charlotte is August, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from Knoxville to Charlotte on May 25, 2026 with Delta Air Lines, with prices starting at $105.
  • You can land at any one of the following hubs in Charlotte, with Mcghee Tyson Airport to Charlotte Douglas International Airport (TYS-CLT) is by far the most common option on this route: Charlotte Douglas International Airport (CLT).
  • The time difference between Charlotte and Knoxville is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.