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Flights from Knoxville to Syracuse

Find flight deals from Knoxville to Syracuse for the next 3 months. Book one way flights from $108 or round trip flights from $281.

      • TYS 11:57 AM
        6h 2m
        1 stop
        SYR 5:59 PM
        Knoxville - Syracuse | Sat, Aug 1 | Delta Air Lines
        SYR 7:17 PM
        4h 37m
        1 stop
        TYS 11:54 PM
        Syracuse - Knoxville | Fri, Aug 7 | Delta Air Lines
        $281 $405
        31% off
        31% off
        $405 $281
      • TYS 3:59 PM
        6h 59m
        1 stop
        SYR 10:58 PM
        Knoxville - Syracuse | Mon, Aug 3 | Delta Air Lines
        SYR 7:17 PM
        4h 35m
        1 stop
        TYS 11:52 PM
        Syracuse - Knoxville | Sun, Aug 9 | Delta Air Lines
        $281 $405
        31% off
        31% off
        $405 $281
      • TYS 5:40 AM
        5h 53m
        1 stop
        SYR 11:33 AM
        Knoxville - Syracuse | Fri, Aug 7 | Delta Air Lines
        SYR 12:33 PM
        6h 23m
        1 stop
        TYS 6:56 PM
        Syracuse - Knoxville | Thu, Aug 13 | Delta Air Lines
        $281 $405
        31% off
        31% off
        $405 $281
      • TYS 5:35 PM
        5h 37m
        1 stop
        SYR 11:12 PM
        Knoxville - Syracuse | Sat, Jul 25 | Delta Air Lines
        SYR 5:45 AM
        5h 13m
        1 stop
        TYS 10:58 AM
        Syracuse - Knoxville | Fri, Jul 31 | Delta Air Lines
        $288
        28% off
        $405 $288
      • TYS 7:15 AM
        4h 54m
        1 stop
        SYR 12:09 PM
        Knoxville - Syracuse | Mon, Sep 7 | Delta Air Lines
        SYR 6:20 AM
        3h 49m
        1 stop
        TYS 10:09 AM
        Syracuse - Knoxville | Tue, Sep 8 | Delta Air Lines
        $289
        28% off
        $405 $289
      • TYS 11:00 AM
        6h 29m
        1 stop
        SYR 5:29 PM
        Knoxville - Syracuse | Sat, Aug 29 | Delta Air Lines
        SYR 7:17 PM
        4h 35m
        1 stop
        TYS 11:52 PM
        Syracuse - Knoxville | Sat, Sep 5 | Delta Air Lines
        $290
        28% off
        $405 $290
      • TYS 5:40 AM
        5h 53m
        1 stop
        SYR 11:33 AM
        Knoxville - Syracuse | Thu, Aug 6 | Delta Air Lines
        SYR 6:10 AM
        5h 1m
        1 stop
        TYS 11:11 AM
        Syracuse - Knoxville | Wed, Aug 12 | Delta Air Lines
        $293
        28% off
        $405 $293
      • TYS 7:43 PM
        4h 5m
        1 stop
        SYR 11:48 PM
        Knoxville - Syracuse | Fri, Jul 24 | Delta Air Lines
        SYR 6:00 AM
        7h 16m
        1 stop
        TYS 1:16 PM
        Syracuse - Knoxville | Thu, Jul 30 | Delta Air Lines
        $322
        20% off
        $405 $322
      • TYS 6:05 AM
        5h 31m
        1 stop
        SYR 11:36 AM
        Knoxville - Syracuse | Thu, Jul 30 | Delta Air Lines
        SYR 6:00 AM
        4h 58m
        1 stop
        TYS 10:58 AM
        Syracuse - Knoxville | Thu, Aug 6 | Delta Air Lines
        $324
        20% off
        $405 $324
      • TYS 7:17 PM
        5h 3m
        1 stop
        SYR 12:20 AM
        Knoxville - Syracuse | Fri, Jul 24 | American Airlines
        SYR 7:34 PM
        4h 17m
        1 stop
        TYS 11:51 PM
        Syracuse - Knoxville | Thu, Jul 30 | American Airlines
        $356
        12% off
        $405 $356
      • TYS 1:00 PM
        17h 25m
        1 stop
        SYR 2:00 PM
        Knoxville - Syracuse | Wed, Jul 22 | Normal Airline
        SYR 3:00 PM
        6h
        Nonstop
        TYS 4:00 PM
        Syracuse - Knoxville | Fri, Jul 24 | Normal Airline
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      • TYS 1:36 PM
        6h 15m
        1 stop
        SYR 7:51 PM
        Knoxville - Syracuse | Tue, Aug 11 | Allegiant Air
        $108 $310
        65% off
        65% off
        $310 $108
      • TYS 6:54 PM
        23h 47m
        1 stop
        SYR 6:41 PM
        Knoxville - Syracuse | Mon, Aug 3 | Allegiant Air
        $118 $310
        62% off
        62% off
        $310 $118
      • TYS 1:36 PM
        6h 15m
        1 stop
        SYR 7:51 PM
        Knoxville - Syracuse | Sat, Aug 8 | Allegiant Air
        $183 $310
        41% off
        41% off
        $310 $183
      • TYS 6:12 PM
        5h 46m
        1 stop
        SYR 11:58 PM
        Knoxville - Syracuse | Thu, Aug 13 | Delta Air Lines
        $266
        14% off
        $310 $266
      • TYS 5:40 AM
        5h 53m
        1 stop
        SYR 11:33 AM
        Knoxville - Syracuse | Wed, Aug 5 | Delta Air Lines
        $268
        14% off
        $310 $268
      • TYS 5:40 AM
        5h 53m
        1 stop
        SYR 11:33 AM
        Knoxville - Syracuse | Thu, Aug 6 | Delta Air Lines
        $268
        14% off
        $310 $268
      • TYS 7:43 PM
        4h 5m
        1 stop
        SYR 11:48 PM
        Knoxville - Syracuse | Wed, Jul 22 | Delta Air Lines
        $271
        13% off
        $310 $271
      • TYS 6:05 PM
        5h 43m
        1 stop
        SYR 11:48 PM
        Knoxville - Syracuse | Tue, Jul 21 | Delta Air Lines
        $272
        12% off
        $310 $272
      • TYS 6:05 AM
        5h 31m
        1 stop
        SYR 11:36 AM
        Knoxville - Syracuse | Mon, Aug 3 | Delta Air Lines
        $272
        12% off
        $310 $272
      • TYS 7:30 AM
        4h 3m
        1 stop
        SYR 11:33 AM
        Knoxville - Syracuse | Thu, Aug 27 | Delta Air Lines
        $272
        12% off
        $310 $272
      • TYS 1:00 PM
        17h 25m
        1 stop
        SYR 2:00 PM
        Knoxville - Syracuse | Wed, Jul 22 | Normal Airline
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Find cheap airlines flights from Knoxville to Syracuse

You can choose from 1 airlines that fly from Knoxville to Syracuse, including American Airlines, Allegiant Air has lowest fares on this route.
American Airlines logo American Airlines
Airlines are determined based on actual purchased flight tickets from Knoxville to Syracuse according to previous 12 months data from Trip.com.

Flight Info | Knoxville to Syracuse

The distance between Knoxville and Syracuse is approximately 1,056.06 km. Based on Trip.com's data travel demand peaks in July. The off-season for travel is September.

Cheapest one-way flight price$108
Cheapest round-trip ticket price$281
Off-season for travelSeptember
Peak season for travelJuly
Flight distance1,056.06 km
Popular airlineAmerican Airlines
Flight statistics for the Knoxville–Syracuse route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Knoxville to Syracuse (TYS-SYR)?

    Based on Trip.com data, Allegiant Air offers one-way fares as low as $108 on Cheapest nonstop routes (e.g. TYS to SYR on Tue, Aug 11), while Delta Air Lines offers Cheapest nonstop round-trips from $281 departing on Sat, Aug 1 and returning on Fri, Aug 7.
  • At the moment, several airlines serve connecting flights from Knoxville to Syracuse, including: American Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Knoxville to Syracuse is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Knoxville to Syracuse, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Tue, Aug 11, with one-way flights priced at just $108.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Allegiant Air.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Syracuse travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Knoxville to Syracuse is September, when demand for travel is lower.
  • After crunching the numbers on our July flight calendar, it's currently cheapest to fly from Knoxville to Syracuse on July 21, 2026 with Delta Air Lines, with prices starting at $271.
  • You can land at any one of the following hubs in Syracuse, with Mcghee Tyson Airport to Syracuse Hancock International Airport (TYS-SYR) is by far the most common option on this route: Syracuse Hancock International Airport (SYR).
  • The time difference between Syracuse and Knoxville is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Explore More Popular Flights

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.