Cheap Flights from Madrid to Santa Cruz from $372

Frequently Asked Questions

• What are the cheapest flights from Madrid to Santa Cruz (MAD-SRZ)?

  Based on Trip.com data, avianca offers one-way fares as low as $372 on Cheapest nonstop routes (e.g. MAD to VVI on Sat, Sep 5), while Air Europa offers Cheapest nonstop round-trips from $895 departing on Mon, Oct 12 and returning on Thu, Oct 15.

• Which airlines offer direct flights from Madrid to Santa Cruz?

  At the moment, you can catch a nonstop flight from Madrid to Santa Cruz with the following airlines, including: Boliviana De Aviación Air Europa Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long does it take to fly from Madrid (MAD) to Santa Cruz (SRZ) and what is the distance?

  It takes around 11 hours 5 minutes to fly from Madrid (MAD) to Santa Cruz (SRZ).

• When is the best time to book flights from Madrid to Santa Cruz?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Madrid to Santa Cruz is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Madrid to Santa Cruz?

  Based on Trip.com data in the past 4 weeks, there is 12 flight per week flying from Madrid to Santa Cruz. You can check the weekly schedule for popular airlines on this route below: Boliviana De Aviación: S/-/T/-/T/-/S -- OB777 (14:59) Air Europa: S/-/T/-/-/F/S -- UX025 (00:05)

• How can I find the best deals on flights from Madrid to Santa Cruz?

  To find best deals on flights from Madrid to Santa Cruz, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sat, Sep 5, with one-way flights priced at just $372.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Air Europa.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Santa Cruz travel is around July.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Madrid (MAD) to Santa Cruz (SRZ) the cheapest?

  The cheapest months to fly from Madrid to Santa Cruz is September, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Madrid to Santa Cruz on?

  After crunching the numbers on our August flight calendar, it's currently cheapest to fly from Madrid to Santa Cruz on August 28, 2026 with avianca, with prices starting at $378.

• Which airports can I fly to for Santa Cruz from Madrid?

  You can land at any one of the following hubs in Santa Cruz, with Madrid Barajas Airport to Viru Viru International Airport (MAD-VVI) is by far the most common option on this route: Viru Viru International Airport (VVI).

• Is there any time difference between Madrid and Santa Cruz?

  The time difference between Santa Cruz and Madrid is 5h.

• How do I change or cancel my ticket from Madrid to Santa Cruz?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from Madrid to Santa Cruz?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Madrid to Santa Cruz is $754. Fares vary by travel date, airline and availability.

• What is the average cost of a round-trip flight from Madrid to Santa Cruz?

  Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Madrid to Santa Cruz is $1,586. The final price depends on the outbound and return dates, airline and fare conditions.

• How do I book flights from Madrid to Santa Cruz on Trip.com?

  Enter Madrid and Santa Cruz, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.

• Are there budget airlines on the Madrid to Santa Cruz route?

  Gol Linhas Aereas Inteligentesare the most popular budget airlines flying from Madrid to Santa Cruz. Check baggage, seat and payment fees before comparing the final price.