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Flights from Madrid to Sao Tome Island

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

      • MAD 6:35 AM
        13h 10m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Sun, May 24 | TAP Air Portugal
        TMS 7:40 PM
        23h 45m
        1 stop
        MAD 9:25 PM
        Sao Tome Island - Madrid | Sun, May 31 | TAP Air Portugal
        $875 $1,204
        27% off
        27% off
        $1,204 $875
      • MAD 10:25 PM
        21h 20m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Thu, May 28 | TAP Air Portugal
        TMS 7:40 PM
        21h 30m
        1 stop
        MAD 7:10 PM
        Sao Tome Island - Madrid | Sun, May 31 | TAP Air Portugal
        $911 $1,204
        24% off
        24% off
        $1,204 $911
      • MAD 6:35 AM
        13h 10m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Sun, Jun 7 | TAP Air Portugal
        TMS 7:40 PM
        26h 40m
        1 stop
        MAD 12:20 AM
        Sao Tome Island - Madrid | Sun, Jun 14 | TAP Air Portugal
        $926 $1,204
        23% off
        23% off
        $1,204 $926
      • MAD 10:25 PM
        21h 20m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Thu, May 28 | easyJet
        TMS 7:40 PM
        19h 15m
        1 stop
        MAD 4:55 PM
        Sao Tome Island - Madrid | Sun, May 31 | TAP Air Portugal
        $936
        22% off
        $1,204 $936
      • MAD 6:00 PM
        25h 45m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Sat, May 30 | TAP Air Portugal
        TMS 7:40 PM
        23h 45m
        1 stop
        MAD 9:25 PM
        Sao Tome Island - Madrid | Sun, Jun 7 | TAP Air Portugal
        $950
        21% off
        $1,204 $950
      • MAD 10:25 PM
        21h
        1 stop
        TMS 5:25 PM
        Madrid - Sao Tome Island | Fri, May 22 | TAP Air Portugal
        TMS 7:40 PM
        26h 40m
        1 stop
        MAD 12:20 AM
        Sao Tome Island - Madrid | Sun, May 24 | TAP Air Portugal
        $962
        20% off
        $1,204 $962
      • MAD 7:40 AM
        12h 5m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Wed, Jun 3 | TAP Air Portugal
        TMS 9:35 PM
        10h 30m
        1 stop
        MAD 10:05 AM
        Sao Tome Island - Madrid | Sat, Jun 6 | TAP Air Portugal
        $977
        19% off
        $1,204 $977
      • MAD 6:30 AM
        13h 15m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Sun, May 24 | Air Europa
        TMS 7:40 PM
        12h 10m
        1 stop
        MAD 9:50 AM
        Sao Tome Island - Madrid | Sun, May 31 | TAP Air Portugal
        $977
        19% off
        $1,204 $977
      • MAD 11:00 PM
        20h 45m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Thu, May 28 | Iberia
        TMS 7:40 PM
        25h 30m
        1 stop
        MAD 11:10 PM
        Sao Tome Island - Madrid | Sun, May 31 | TAP Air Portugal
        $986
        18% off
        $1,204 $986
      • MAD 6:30 AM
        13h 15m
        1 stop
        TMS 5:45 PM
        Madrid - Sao Tome Island | Sun, Jun 7 | Air Europa
        TMS 7:40 PM
        12h 10m
        1 stop
        MAD 9:50 AM
        Sao Tome Island - Madrid | Sun, Jun 14 | TAP Air Portugal
        $987
        18% off
        $1,204 $987
      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
        TMS 3:00 PM
        6h
        Nonstop
        MAD 4:00 PM
        Sao Tome Island - Madrid | Sun, May 24 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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        Search
      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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      • MAD 1:00 PM
        17h 25m
        1 stop
        TMS 2:00 PM
        Madrid - Sao Tome Island | Fri, May 22 | Normal Airline
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Displayed flight fares from Madrid to Sao Tome Island are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Frequently Asked Questions

  • When is the best time to book flights from Madrid to Sao Tome Island?

    By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Madrid to Sao Tome Island is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Madrid to Sao Tome Island, you can use various tools on Trip.com:
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Sao Tome Island travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Madrid to Sao Tome Island is November, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from Madrid to Sao Tome Island on May 24, 2026 with TAP Air Portugal, with prices starting at $875.
  • The time difference between Sao Tome Island and Madrid is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

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Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.