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Flights from Minneapolis to Key West

Find flight deals from Minneapolis to Key West for the next 3 months. Book one way flights from $368 or round trip flights from $339.

      • MSP 10:45 AM
        7h 4m
        1 stop
        EYW 6:49 PM
        Minneapolis - Key West | Sun, May 31 | American Airlines
        EYW 7:40 PM
        5h 42m
        1 stop
        MSP 12:22 AM
        Key West - Minneapolis | Fri, Jun 5 | American Airlines
        $339 $572
        41% off
        41% off
        $572 $339
      • MSP 1:48 PM
        7h 48m
        1 stop
        EYW 10:36 PM
        Minneapolis - Key West | Tue, May 19 | American Airlines
        EYW 5:03 PM
        7h 56m
        1 stop
        MSP 11:59 PM
        Key West - Minneapolis | Fri, May 22 | American Airlines
        $366 $572
        36% off
        36% off
        $572 $366
      • MSP 12:45 PM
        6h 4m
        1 stop
        EYW 7:49 PM
        Minneapolis - Key West | Sat, May 30 | Delta Air Lines
        EYW 11:48 AM
        6h 35m
        1 stop
        MSP 5:23 PM
        Key West - Minneapolis | Sat, Jun 6 | Delta Air Lines
        $402 $572
        30% off
        30% off
        $572 $402
      • MSP 5:20 AM
        6h 7m
        1 stop
        EYW 12:27 PM
        Minneapolis - Key West | Fri, May 22 | Delta Air Lines
        EYW 7:30 AM
        7h 20m
        1 stop
        MSP 1:50 PM
        Key West - Minneapolis | Tue, May 26 | Delta Air Lines
        $425
        26% off
        $572 $425
      • MSP 5:20 AM
        6h 40m
        1 stop
        EYW 1:00 PM
        Minneapolis - Key West | Mon, Jun 8 | Delta Air Lines
        EYW 6:24 PM
        6h 53m
        1 stop
        MSP 12:17 AM
        Key West - Minneapolis | Sun, Jun 14 | Delta Air Lines
        $436
        24% off
        $572 $436
      • MSP 10:45 AM
        7h 4m
        1 stop
        EYW 6:49 PM
        Minneapolis - Key West | Mon, Jun 8 | American Airlines
        EYW 7:40 PM
        5h 42m
        1 stop
        MSP 12:22 AM
        Key West - Minneapolis | Sun, Jun 14 | American Airlines
        $451
        21% off
        $572 $451
      • MSP 10:45 AM
        7h 4m
        1 stop
        EYW 6:49 PM
        Minneapolis - Key West | Thu, Jun 4 | American Airlines
        EYW 7:40 PM
        5h 42m
        1 stop
        MSP 12:22 AM
        Key West - Minneapolis | Thu, Jun 11 | American Airlines
        $455
        20% off
        $572 $455
      • MSP 7:30 AM
        7h 32m
        1 stop
        EYW 4:02 PM
        Minneapolis - Key West | Sat, May 16 | United Airlines
        EYW 4:47 PM
        7h 12m
        1 stop
        MSP 10:59 PM
        Key West - Minneapolis | Tue, May 19 | United Airlines
        $466
        19% off
        $572 $466
      • MSP 7:30 AM
        7h 32m
        1 stop
        EYW 4:02 PM
        Minneapolis - Key West | Thu, May 14 | United Airlines
        EYW 4:47 PM
        7h 12m
        1 stop
        MSP 10:59 PM
        Key West - Minneapolis | Tue, May 19 | United Airlines
        $468
        18% off
        $572 $468
      • MSP 1:48 PM
        7h 48m
        1 stop
        EYW 10:36 PM
        Minneapolis - Key West | Mon, May 18 | American Airlines
        EYW 6:49 PM
        6h 10m
        1 stop
        MSP 11:59 PM
        Key West - Minneapolis | Fri, May 22 | American Airlines
        $474
        17% off
        $572 $474
      • MSP 1:00 PM
        17h 25m
        1 stop
        EYW 2:00 PM
        Minneapolis - Key West | Fri, May 15 | Normal Airline
        EYW 3:00 PM
        6h
        Nonstop
        MSP 4:00 PM
        Key West - Minneapolis | Sun, May 17 | Normal Airline
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      • MSP 7:07 AM
        10h 9m
        1 stop
        EYW 6:16 PM
        Minneapolis - Key West | Tue, May 19 | American Airlines
        $368 $475
        23% off
        23% off
        $475 $368
      • MSP 5:20 AM
        7h 9m
        1 stop
        EYW 1:29 PM
        Minneapolis - Key West | Sat, Jul 11 | Delta Air Lines
        $378 $475
        20% off
        20% off
        $475 $378
      • MSP 9:00 AM
        7h 23m
        1 stop
        EYW 5:23 PM
        Minneapolis - Key West | Fri, May 29 | Delta Air Lines
        $380 $475
        20% off
        20% off
        $475 $380
      • MSP 8:28 AM
        7h 59m
        1 stop
        EYW 5:27 PM
        Minneapolis - Key West | Wed, Jun 17 | Delta Air Lines
        $382
        20% off
        $475 $382
      • MSP 6:00 AM
        8h 7m
        1 stop
        EYW 3:07 PM
        Minneapolis - Key West | Sat, Jul 11 | United Airlines
        $386
        19% off
        $475 $386
      • MSP 12:45 PM
        6h 8m
        1 stop
        EYW 7:53 PM
        Minneapolis - Key West | Sat, Jun 13 | Delta Air Lines
        $389
        18% off
        $475 $389
      • MSP 6:00 AM
        8h 7m
        1 stop
        EYW 3:07 PM
        Minneapolis - Key West | Mon, Jun 15 | United Airlines
        $391
        18% off
        $475 $391
      • MSP 7:00 AM
        5h 28m
        1 stop
        EYW 1:28 PM
        Minneapolis - Key West | Thu, Jun 18 | Delta Air Lines
        $391
        18% off
        $475 $391
      • MSP 5:20 AM
        7h 8m
        1 stop
        EYW 1:28 PM
        Minneapolis - Key West | Mon, Jun 15 | Delta Air Lines
        $392
        17% off
        $475 $392
      • MSP 6:00 AM
        8h 7m
        1 stop
        EYW 3:07 PM
        Minneapolis - Key West | Thu, Jun 18 | United Airlines
        $394
        17% off
        $475 $394
      • MSP 1:00 PM
        17h 25m
        1 stop
        EYW 2:00 PM
        Minneapolis - Key West | Fri, May 15 | Normal Airline
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        Find more flights

Displayed flight fares from Minneapolis to Key West are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Frequently Asked Questions

  • What are the cheapest flights from Minneapolis to Key West (MSP-EYW)?

    Based on Trip.com data, American Airlines offers one-way fares as low as $368 on Cheapest nonstop routes (e.g. MSP to EYW on Tue, May 19), while American Airlines offers Cheapest nonstop round-trips from $339 departing on Sun, May 31 and returning on Fri, Jun 5.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Minneapolis to Key West is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Minneapolis to Key West, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Tue, May 19, with one-way flights priced at just $368.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Key West travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Minneapolis to Key West is August, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from Minneapolis to Key West on May 28, 2026 with American Airlines, with prices starting at $339.
  • The time difference between Key West and Minneapolis is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.