Cheap Flights from Panama City to Chicago from $329

Frequently Asked Questions

• What are the cheapest flights from Panama City to Chicago (PTY-CHI)?

  Based on Trip.com data, Delta Air Lines offers one-way fares as low as $329 on Cheapest nonstop routes (e.g. PTY to MDW on Tue, Nov 3), while avianca offers Cheapest nonstop round-trips from $437 departing on Sun, Nov 1 and returning on Wed, Nov 4.

• Which airlines offer direct flights from Panama City to Chicago?

  At the moment, you can catch a nonstop flight from Panama City to Chicago with the following airlines, including: avianca Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long does it take to fly from Panama City (PTY) to Chicago (CHI) and what is the distance?

  It takes around 5 hours 40 minutes to fly from Panama City (PTY) to Chicago (CHI).

• When is the best time to book flights from Panama City to Chicago?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Panama City to Chicago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Panama City to Chicago?

  Based on Trip.com data in the past 4 weeks, there is 22 flight per week flying from Panama City to Chicago. You can check the weekly schedule for popular airlines on this route below: United Airlines: S/M/T/W/T/F/S -- UA7171 (08:07)

• How can I find the best deals on flights from Panama City to Chicago?

  To find best deals on flights from Panama City to Chicago, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Tue, Nov 3, with one-way flights priced at just $329.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Copa Airlines.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Chicago travel is around January.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Panama City (PTY) to Chicago (CHI) the cheapest?

  The cheapest months to fly from Panama City to Chicago is August, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Panama City to Chicago on?

  After crunching the numbers on our October flight calendar, it's currently cheapest to fly from Panama City to Chicago on October 28, 2026 with Copa Airlines, with prices starting at $396.

• Which airports can I fly into Chicago from Panama City?

  You can arrive at any of the following airports in Chicago: O'Hare International Airport (ORD), Chicago Midway International Airport (MDW), and Chicago Rockford International Airport (RFD). Flights from Tocumen International Airport to Chicago Midway International Airport (PTY-MDW) are by far the most popular option for this route.

• Is there any time difference between Panama City and Chicago?

  The time difference between Chicago and Panama City is 1h.

• How do I change or cancel my ticket from Panama City to Chicago?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from Panama City to Chicago?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Panama City to Chicago is $701. Fares vary by travel date, airline and availability.

• What is the average cost of a round-trip flight from Panama City to Chicago?

  Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Panama City to Chicago is $950. The final price depends on the outbound and return dates, airline and fare conditions.

• How do I book flights from Panama City to Chicago on Trip.com?

  Enter Panama City and Chicago, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.