Trip.com
>
Flights
>
Flights to United States
>
Flights to Florida
>
Flights to Key West
Hotels in Key West
>
Flights from San Diego to Key West

Find flight deals from San Diego to Key West for the next 3 months. Book one way flights from $346 or round trip flights from $299.

      • SAN 12:53 PM
        7h 4m
        1 stop
        EYW 10:57 PM
        San Diego - Key West | Wed, Apr 8 | American Airlines
        EYW 2:01 PM
        9h 51m
        1 stop
        SAN 8:52 PM
        Key West - San Diego | Thu, Apr 16 | American Airlines
        $299 $475
        37% off
        37% off
        $475 $299
      • SAN 9:45 PM
        10h 5m
        1 stop
        EYW 10:50 AM
        San Diego - Key West | Fri, Apr 24 | Delta Air Lines
        EYW 6:19 PM
        8h 6m
        1 stop
        SAN 11:25 PM
        Key West - San Diego | Tue, Apr 28 | Delta Air Lines
        $302 $475
        36% off
        36% off
        $475 $302
      • SAN 12:53 PM
        7h 4m
        1 stop
        EYW 10:57 PM
        San Diego - Key West | Mon, Apr 13 | American Airlines
        EYW 2:01 PM
        9h 51m
        1 stop
        SAN 8:52 PM
        Key West - San Diego | Fri, Apr 17 | American Airlines
        $328 $475
        31% off
        31% off
        $475 $328
      • SAN 10:30 PM
        9h 22m
        1 stop
        EYW 10:52 AM
        San Diego - Key West | Mon, Apr 13 | Delta Air Lines
        EYW 2:40 PM
        9h 7m
        1 stop
        SAN 8:47 PM
        Key West - San Diego | Fri, Apr 17 | Delta Air Lines
        $364
        23% off
        $475 $364
      • SAN 6:15 AM
        9h 34m
        1 stop
        EYW 6:49 PM
        San Diego - Key West | Sun, Apr 12 | American Airlines
        EYW 2:01 PM
        9h 49m
        1 stop
        SAN 8:50 PM
        Key West - San Diego | Thu, Apr 16 | American Airlines
        $368
        23% off
        $475 $368
      • SAN 8:00 AM
        8h 40m
        1 stop
        EYW 7:40 PM
        San Diego - Key West | Wed, Apr 15 | Delta Air Lines
        EYW 6:23 PM
        8h 2m
        1 stop
        SAN 11:25 PM
        Key West - San Diego | Tue, Apr 21 | Delta Air Lines
        $379
        20% off
        $475 $379
      • SAN 9:45 PM
        10h 1m
        1 stop
        EYW 10:46 AM
        San Diego - Key West | Fri, May 1 | Delta Air Lines
        EYW 6:19 PM
        8h 8m
        1 stop
        SAN 11:27 PM
        Key West - San Diego | Fri, May 8 | Delta Air Lines
        $386
        19% off
        $475 $386
      • SAN 10:43 PM
        10h 18m
        1 stop
        EYW 12:01 PM
        San Diego - Key West | Mon, Mar 23 | American Airlines
        EYW 3:56 PM
        9h 54m
        1 stop
        SAN 10:50 PM
        Key West - San Diego | Thu, Mar 26 | American Airlines
        $391
        18% off
        $475 $391
      • SAN 8:59 PM
        12h
        1 stop
        EYW 11:59 AM
        San Diego - Key West | Mon, Mar 23 | Jetblue Airways
        EYW 12:55 PM
        9h 14m
        1 stop
        SAN 7:09 PM
        Key West - San Diego | Wed, Mar 25 | American Airlines
        $393
        17% off
        $475 $393
      • SAN 12:53 PM
        7h 5m
        1 stop
        EYW 10:58 PM
        San Diego - Key West | Tue, Apr 14 | American Airlines
        EYW 6:45 AM
        8h 8m
        1 stop
        SAN 11:53 AM
        Key West - San Diego | Fri, Apr 17 | American Airlines
        $413
        13% off
        $475 $413
      • SAN 1:00 PM
        17h 25m
        1 stop
        EYW Invalid Date
        San Diego - Key West | Tue, Mar 17 | Normal Airline
        EYW 3:00 PM
        6h
        Nonstop
        SAN 4:00 PM
        Key West - San Diego | Thu, Mar 19 | Normal Airline
        Find more flights
        Find more flights
      • SAN 10:02 PM
        14h 49m
        1 stop
        EYW 3:51 PM
        San Diego - Key West | Wed, Mar 18 | Hawaiian Airlines
        $346 $629
        45% off
        45% off
        $629 $346
      • SAN 10:02 PM
        14h 49m
        1 stop
        EYW 3:51 PM
        San Diego - Key West | Wed, Mar 18 | Alaska Airlines
        $348 $629
        45% off
        45% off
        $629 $348
      • SAN 9:55 PM
        9h 53m
        1 stop
        EYW 10:48 AM
        San Diego - Key West | Wed, Mar 18 | Delta Air Lines
        $375 $629
        40% off
        40% off
        $629 $375
      • SAN 11:03 AM
        8h 16m
        1 stop
        EYW 10:19 PM
        San Diego - Key West | Wed, Mar 18 | United Airlines
        $456
        28% off
        $629 $456
      • SAN 8:59 PM
        12h
        1 stop
        EYW 11:59 AM
        San Diego - Key West | Wed, Mar 18 | Jetblue Airways
        $547
        13% off
        $629 $547
      • SAN 1:00 PM
        17h 25m
        1 stop
        EYW Invalid Date
        San Diego - Key West | Tue, Mar 17 | Normal Airline
        Find more flights
        Find more flights

Displayed flight fares from San Diego to Key West are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flight Info | San Diego to Key West

The distance between San Diego and Key West is approximately 3,556.01 km. Based on Trip.com's data travel demand peaks in December. The off-season for travel is September.

Cheapest one-way flight price$346
Cheapest round-trip ticket price$299
Off-season for travelSeptember
Peak season for travelDecember
Flight distance3,556.01 km
Flight statistics for the San Diego–Key West route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from San Diego to Key West (SAN-EYW)?

    Based on Trip.com data, Hawaiian Airlines offers one-way fares as low as $346 on Cheapest nonstop routes (e.g. SAN to EYW on Wed, Mar 18), while American Airlines offers Cheapest nonstop round-trips from $299 departing on Wed, Apr 8 and returning on Thu, Apr 16.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from San Diego to Key West is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from San Diego to Key West, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Mar 18, with one-way flights priced at just $346.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Hawaiian Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Key West travel is around December.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from San Diego to Key West is September, when demand for travel is lower.
  • After crunching the numbers on our March flight calendar, it's currently cheapest to fly from San Diego to Key West on March 23, 2026 with American Airlines, with prices starting at $391.
  • The time difference between Key West and San Diego is 3h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Explore More Popular Flights

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.