Cheap Flights from San Francisco to Guayaquil from $227

Frequently Asked Questions

• What are the cheapest flights from San Francisco to Guayaquil (SFO-GYE)?

  Based on Trip.com data, American Airlines offers one-way fares as low as $227 on Cheapest nonstop routes (e.g. SFO to GYE on Sun, Oct 11), while American Airlines offers Cheapest nonstop round-trips from $588 departing on Fri, Oct 9 and returning on Fri, Oct 16.

• Which airlines offer flights from San Francisco to Guayaquil?

  At the moment, several airlines serve connecting flights from San Francisco to Guayaquil, including: Copa Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.

• When is the best time to book flights from San Francisco to Guayaquil?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from San Francisco to Guayaquil is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How can I find the best deals on flights from San Francisco to Guayaquil?

  To find best deals on flights from San Francisco to Guayaquil, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sun, Oct 11, with one-way flights priced at just $227.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Guayaquil travel is around July.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from San Francisco (SFO) to Guayaquil (GYE) the cheapest?

  The cheapest months to fly from San Francisco to Guayaquil is October, when demand for travel is lower.

• Which upcoming date is cheapest to fly from San Francisco to Guayaquil on?

  After crunching the numbers on our August flight calendar, it's currently cheapest to fly from San Francisco to Guayaquil on August 19, 2026 with Copa Airlines, with prices starting at $630.

• Which airports can I fly to for Guayaquil from San Francisco?

  You can land at any one of the following hubs in Guayaquil, with San Francisco International Airport to José Joaquín de Olmedo International Airport (SFO-GYE) is by far the most common option on this route: José Joaquín de Olmedo International Airport (GYE).

• Is there any time difference between San Francisco and Guayaquil?

  The time difference between Guayaquil and San Francisco is 3h.

• How do I change or cancel my ticket from San Francisco to Guayaquil?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from San Francisco to Guayaquil?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from San Francisco to Guayaquil is $737. Fares vary by travel date, airline and availability.

• How do I book flights from San Francisco to Guayaquil on Trip.com?

  Enter San Francisco and Guayaquil, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.