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Flights from San Francisco to Medellin

Find flight deals from San Francisco to Medellin for the next 3 months. Book one way flights from $130 or round trip flights from $494.

      • SFO 8:06 PM
        11h 34m
        1 stop
        MDE 9:40 AM
        San Francisco - Medellin | Wed, May 20 | Copa Airlines
        MDE 4:30 PM
        33h 10m
        1 stop
        SFO 11:40 PM
        Medellin - San Francisco | Mon, May 25 | Copa Airlines
        $494 $760
        35% off
        35% off
        $760 $494
      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Fri, May 29 | United Airlines
        MDE 9:45 AM
        16h 20m
        1 stop
        SFO 12:05 AM
        Medellin - San Francisco | Thu, Jun 4 | United Airlines
        $586 $760
        23% off
        23% off
        $760 $586
      • SFO 5:00 AM
        14h 10m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Mon, May 25 | United Airlines
        MDE 9:45 AM
        16h 30m
        1 stop
        SFO 12:15 AM
        Medellin - San Francisco | Fri, May 29 | United Airlines
        $586 $760
        23% off
        23% off
        $760 $586
      • SFO 6:54 PM
        24h 16m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Thu, Jul 2 | United Airlines
        MDE 9:45 AM
        16h 30m
        1 stop
        SFO 12:15 AM
        Medellin - San Francisco | Wed, Jul 8 | United Airlines
        $595
        22% off
        $760 $595
      • SFO 8:06 PM
        16h 9m
        1 stop
        MDE 2:15 PM
        San Francisco - Medellin | Thu, May 21 | Copa Airlines
        MDE 4:30 PM
        33h 10m
        1 stop
        SFO 11:40 PM
        Medellin - San Francisco | Mon, May 25 | Copa Airlines
        $615
        19% off
        $760 $615
      • SFO 8:16 PM
        15h 59m
        1 stop
        MDE 2:15 PM
        San Francisco - Medellin | Sat, May 30 | Copa Airlines
        MDE 6:00 AM
        19h 44m
        1 stop
        SFO 11:44 PM
        Medellin - San Francisco | Fri, Jun 5 | American Airlines
        $626
        18% off
        $760 $626
      • SFO 8:16 PM
        9h 59m
        1 stop
        MDE 8:15 AM
        San Francisco - Medellin | Wed, Jun 3 | Copa Airlines
        MDE 6:00 AM
        19h 44m
        1 stop
        SFO 11:44 PM
        Medellin - San Francisco | Fri, Jun 5 | American Airlines
        $626
        18% off
        $760 $626
      • SFO 8:16 PM
        9h 59m
        1 stop
        MDE 8:15 AM
        San Francisco - Medellin | Thu, Jun 4 | Copa Airlines
        MDE 6:20 PM
        25h 54m
        1 stop
        SFO 6:14 PM
        Medellin - San Francisco | Wed, Jun 10 | Copa Airlines
        $628
        17% off
        $760 $628
      • SFO 7:45 AM
        10h 30m
        1 stop
        MDE 8:15 PM
        San Francisco - Medellin | Thu, May 21 | American Airlines
        MDE 11:59 PM
        26h
        1 stop
        SFO 11:59 PM
        Medellin - San Francisco | Mon, May 25 | American Airlines
        $629
        17% off
        $760 $629
      • SFO 8:16 PM
        9h 59m
        1 stop
        MDE 8:15 AM
        San Francisco - Medellin | Sat, Jun 6 | Copa Airlines
        MDE 10:35 AM
        15h 5m
        1 stop
        SFO 11:40 PM
        Medellin - San Francisco | Wed, Jun 10 | Copa Airlines
        $630
        17% off
        $760 $630
      • SFO 1:00 PM
        17h 25m
        1 stop
        MDE 2:00 PM
        San Francisco - Medellin | Fri, May 15 | Normal Airline
        MDE 3:00 PM
        6h
        Nonstop
        SFO 4:00 PM
        Medellin - San Francisco | Sun, May 17 | Normal Airline
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      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Sat, May 16 | United Airlines
        $130 $554
        77% off
        77% off
        $554 $130
      • SFO 11:55 PM
        11h 15m
        1 stop
        MDE 1:10 PM
        San Francisco - Medellin | Sat, May 16 | avianca
        $146 $554
        74% off
        74% off
        $554 $146
      • SFO 11:55 PM
        11h 15m
        1 stop
        MDE 1:10 PM
        San Francisco - Medellin | Mon, May 25 | avianca
        $146 $554
        74% off
        74% off
        $554 $146
      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Mon, Jun 22 | United Airlines
        $148
        73% off
        $554 $148
      • SFO 6:54 PM
        24h 16m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Sun, May 24 | United Airlines
        $148
        73% off
        $554 $148
      • SFO 11:55 PM
        11h 15m
        1 stop
        MDE 1:10 PM
        San Francisco - Medellin | Sun, May 17 | avianca
        $150
        73% off
        $554 $150
      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Sun, May 17 | United Airlines
        $153
        72% off
        $554 $153
      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Tue, May 26 | United Airlines
        $158
        71% off
        $554 $158
      • SFO 12:45 AM
        18h 25m
        1 stop
        MDE 9:10 PM
        San Francisco - Medellin | Thu, May 28 | United Airlines
        $307
        45% off
        $554 $307
      • SFO 11:55 PM
        11h 15m
        1 stop
        MDE 1:10 PM
        San Francisco - Medellin | Tue, May 19 | avianca
        $459
        17% off
        $554 $459
      • SFO 1:00 PM
        17h 25m
        1 stop
        MDE 2:00 PM
        San Francisco - Medellin | Fri, May 15 | Normal Airline
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Displayed flight fares from San Francisco to Medellin are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Trip.com price insights on flights from San Francisco to Medellin

Which month has the cheapest one-way flights from to Medellin?

The average price of one-way flights from to Medellin purchased by Trip.com users by month over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from to Medellin is August, with an average price of $239; while the month with the highest flight price is usually December, with an average price of up to $504.

$504
$372
$239
$107
    Cheapest
  • $265
    May
  • $245
    Jun
  • $271
    Jul
  • $239
    Aug
  • $282
    Sep
  • $326
    Oct
  • $305
    Nov
  • $504
    Dec
  • $303
    Jan
  • $265
    Feb
  • $243
    Mar
  • $244
    Apr

When is the cheapest day to fly from San Francisco to Medellin during Memorial Day?

Data is based on the lowest one-way price from San Francisco to Medellin during Memorial Day on Trip.com in the past 3 days.

Memorial Day is scheduled for May 25. The cheapest flights from San Francisco to Medellin are available on May 27, with fares starting at $134.

$265
$200
$134
$69
    Cheapest
  • $184
    22
    May
  • $265
    23
  • $170
    24
  • $146
    25
  • $164
    26
  • $134
    27

Frequently Asked Questions

  • What are the cheapest flights from San Francisco to Medellin (SFO-MDE)?

    Based on Trip.com data, United Airlines offers one-way fares as low as $130 on Cheapest nonstop routes (e.g. SFO to MDE on Sat, May 16), while Copa Airlines offers Cheapest nonstop round-trips from $494 departing on Wed, May 20 and returning on Mon, May 25.
  • At the moment, you can catch a nonstop flight from San Francisco to Medellin with the following airlines, including: Jetblue Airways Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from San Francisco to Medellin is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from San Francisco to Medellin, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sat, May 16, with one-way flights priced at just $130.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is United Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Medellin travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from San Francisco to Medellin is November, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from San Francisco to Medellin on May 16, 2026 with United Airlines, with prices starting at $130.
  • You can land at any one of the following hubs in Medellin, with San Francisco International Airport to Jose Maria Cordova International Airport (SFO-MDE) is by far the most common option on this route: Jose Maria Cordova International Airport (MDE) Olaya Herrera Airport (EOH).
  • The time difference between Medellin and San Francisco is 3h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

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Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.