Cheap Flights from San Francisco to Santiago from $460

Frequently Asked Questions

• What are the cheapest flights from San Francisco to Santiago (SFO-SCL)?

  Based on Trip.com data, Air Canada offers one-way fares as low as $460 on Cheapest nonstop routes (e.g. SFO to SCL on Sun, Oct 25), while Copa Airlines offers Cheapest nonstop round-trips from $761 departing on Wed, Nov 4 and returning on Wed, Nov 11.

• Which airlines offer direct flights from San Francisco to Santiago?

  At the moment, you can catch a nonstop flight from San Francisco to Santiago with the following airlines, including: American Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• When is the best time to book flights from San Francisco to Santiago?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from San Francisco to Santiago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How can I find the best deals on flights from San Francisco to Santiago?

  To find best deals on flights from San Francisco to Santiago, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sun, Oct 25, with one-way flights priced at just $460.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Air Canada.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Santiago travel is around July.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from San Francisco (SFO) to Santiago (SCL) the cheapest?

  The cheapest months to fly from San Francisco to Santiago is November, when demand for travel is lower.

• Which upcoming date is cheapest to fly from San Francisco to Santiago on?

  After crunching the numbers on our September flight calendar, it's currently cheapest to fly from San Francisco to Santiago on September 12, 2026 with Delta Air Lines, with prices starting at $768.

• Which airports can I fly into Santiago from San Francisco?

  You can arrive at any of the following airports in Santiago: Arturo Merino Benitez International Airport (SCL). Flights from San Francisco International Airport to Arturo Merino Benitez International Airport (SFO-SCL) are by far the most popular option for this route.

• Is there any time difference between San Francisco and Santiago?

  The time difference between Santiago and San Francisco is 4h.

• How do I change or cancel my ticket from San Francisco to Santiago?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from San Francisco to Santiago?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from San Francisco to Santiago is $847. Fares vary by travel date, airline and availability.

• How do I book flights from San Francisco to Santiago on Trip.com?

  Enter San Francisco and Santiago, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.