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Flights from Syracuse to Des Moines

Find cheap airlines flights from Syracuse to Des Moines

Choose from 1 carriers that fly from Syracuse to Des Moines, including Delta Air Lines, Enjoy the cheapest tickets on this route with Delta Air Lines.
Delta Air Lines logo Delta Air Lines

Find flight deals from Syracuse to Des Moines for the next 3 months. Book one way flights from $254 or round trip flights from $248.

      • SYR 12:19 PM
        8h 24m
        1 stop
        DSM 7:43 PM
        Syracuse - Des Moines | Fri, Dec 12 | Delta Air Lines
        DSM 5:43 PM
        4h 28m
        1 stop
        SYR 11:11 PM
        Des Moines - Syracuse | Sun, Dec 14 | Delta Air Lines
        $248 $508
        51% OFF
        51% OFF
        $508 $248
      • SYR 9:52 AM
        7h 24m
        1 stop
        DSM 4:16 PM
        Syracuse - Des Moines | Wed, Dec 3 | Delta Air Lines
        DSM 5:43 PM
        4h 28m
        1 stop
        SYR 11:11 PM
        Des Moines - Syracuse | Wed, Dec 10 | Delta Air Lines
        $252 $508
        51% OFF
        51% OFF
        $508 $252
      • SYR 5:46 PM
        7h 2m
        1 stop
        DSM 11:48 PM
        Syracuse - Des Moines | Wed, Dec 3 | American Airlines
        DSM 6:00 AM
        4h 33m
        1 stop
        SYR 11:33 AM
        Des Moines - Syracuse | Wed, Dec 10 | American Airlines
        $261 $508
        49% OFF
        49% OFF
        $508 $261
      • SYR 2:00 PM
        6h 29m
        1 stop
        DSM 7:29 PM
        Syracuse - Des Moines | Fri, Jan 2 | Delta Air Lines
        DSM 5:21 PM
        4h 56m
        1 stop
        SYR 11:17 PM
        Des Moines - Syracuse | Sun, Jan 4 | Delta Air Lines
        $273
        46% OFF
        $508 $273
      • SYR 6:00 AM
        5h 42m
        1 stop
        DSM 10:42 AM
        Syracuse - Des Moines | Thu, Nov 20 | Delta Air Lines
        DSM 5:52 PM
        4h 18m
        1 stop
        SYR 11:10 PM
        Des Moines - Syracuse | Mon, Nov 24 | Delta Air Lines
        $280
        45% OFF
        $508 $280
      • SYR 8:31 AM
        6h 34m
        1 stop
        DSM 2:05 PM
        Syracuse - Des Moines | Wed, Nov 19 | Delta Air Lines
        DSM 5:52 PM
        4h 18m
        1 stop
        SYR 11:10 PM
        Des Moines - Syracuse | Sun, Nov 23 | Delta Air Lines
        $299
        41% OFF
        $508 $299
      • SYR 6:00 AM
        4h 40m
        1 stop
        DSM 9:40 AM
        Syracuse - Des Moines | Fri, Dec 19 | Delta Air Lines
        DSM 5:21 PM
        4h 56m
        1 stop
        SYR 11:17 PM
        Des Moines - Syracuse | Sun, Dec 21 | Delta Air Lines
        $320
        37% OFF
        $508 $320
      • SYR 6:15 AM
        5h 38m
        1 stop
        DSM 10:53 AM
        Syracuse - Des Moines | Wed, Dec 3 | United Airlines
        DSM 3:17 PM
        4h 54m
        1 stop
        SYR 9:11 PM
        Des Moines - Syracuse | Wed, Dec 10 | United Airlines
        $326
        36% OFF
        $508 $326
      • SYR 6:08 AM
        7h 16m
        1 stop
        DSM 12:24 PM
        Syracuse - Des Moines | Thu, Nov 27 | Delta Air Lines
        DSM 5:52 PM
        4h 18m
        1 stop
        SYR 11:10 PM
        Des Moines - Syracuse | Mon, Dec 1 | Delta Air Lines
        $329
        35% OFF
        $508 $329
      • SYR 7:00 AM
        9h 50m
        1 stop
        DSM 3:50 PM
        Syracuse - Des Moines | Thu, Jan 1 | Delta Air Lines
        DSM 5:21 PM
        4h 55m
        1 stop
        SYR 11:16 PM
        Des Moines - Syracuse | Sat, Jan 3 | Delta Air Lines
        $366
        28% OFF
        $508 $366
      • SYR 1:00 PM
        17h 25m
        1 stop
        DSM Invalid Date
        Syracuse - Des Moines | Mon, Nov 17 | Normal Airline
        DSM 3:00 PM
        6h
        Nonstop
        SYR 4:00 PM
        Des Moines - Syracuse | Wed, Nov 19 | Normal Airline
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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Flight Info | Syracuse to Des Moines

The distance between Syracuse and Des Moines is about 1,450.87 km. The most popular month to Des Moines is July. The off-season for travel is October.

Cheapest one-way flight price$254
Cheapest round-trip ticket price$248
Off-season for travelOctober
Peak season for travelJuly
Flight distance1,450.87 km
Popular airlineDelta Air Lines

When is the cheapest time to fly from Syracuse to Des Moines?

The cheapest time for Syracuse to Des Moines flights: Nov 16 to Nov 23 — one way flight prices from $235.

Cheapest flights
From price
Search
  • 916
  • 1623
  • 2330

  • Dec

    307
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • Which airlines offer flights from Syracuse to Des Moines?

    At the moment, several airlines serve connecting flights from Syracuse to Des Moines, including: Delta Air Lines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Syracuse to Des Moines is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • The cheapest months to fly from Syracuse to Des Moines is October, when demand for travel is lower.
  • After crunching the numbers on our November flight calendar, it's currently cheapest to fly from Syracuse to Des Moines on November 20, 2025 with Delta Air Lines, with prices starting at $279.
  • You can land at any one of the following hubs in Des Moines, with Syracuse Hancock International Airport to Des Moines International Airport (SYR-DSM) is by far the most common option on this route: Des Moines International Airport (DSM).
  • The time difference between Des Moines and Syracuse is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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