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Charleston International Airport to Des Moines International Airport flight
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Cheap Flights from Charleston International Airport to Des Moines International Airport

Search for flights from Charleston to Des Moines and check out affordable one-way and round-trip options.

  • One way
  • Round-trip
sortSort by: Lowest Price
  • Sort by: Lowest Price
  • Sort by: Earliest Flight
      • CHS20:18
        4h 47m
        1 stop
        DSM00:05
        Charleston - Des Moines|Fri, Jun 28|American Airlines
        AU$316AU$629
        50% OFF
        50% OFF
        AU$629AU$316
      • CHS06:00
        8h 52m
        1 stop
        DSM13:52
        Charleston - Des Moines|Fri, Jun 28|Delta Air Lines
        AU$386AU$629
        39% OFF
        39% OFF
        AU$629AU$386
      • CHS17:10
        7h 40m
        1 stop
        DSM23:50
        Charleston - Des Moines|Sun, Jun 30|Southwest Airlines
        AU$388AU$629
        38% OFF
        38% OFF
        AU$629AU$388
      • CHS06:00
        9h 19m
        2 stops
        DSM14:19
        Charleston - Des Moines|Fri, Jul 12|Breeze Airways
        AU$395
        AU$395
      • CHS06:15
        5h 12m
        1 stop
        DSM10:27
        Charleston - Des Moines|Sat, Jun 29|United Airlines
        AU$415
        AU$415
      • CHS20:30
        4h 35m
        1 stop
        DSM00:05
        Charleston - Des Moines|Sat, Jun 29|American Airlines
        AU$417
        AU$417
      • CHS20:18
        4h 47m
        1 stop
        DSM00:05
        Charleston - Des Moines|Sun, Jun 30|American Airlines
        AU$418
        AU$418
      • CHS05:30
        5h 45m
        1 stop
        DSM10:15
        Charleston - Des Moines|Sat, Jun 29|Delta Air Lines
        AU$418
        AU$418
      • CHS05:30
        5h 45m
        1 stop
        DSM10:15
        Charleston - Des Moines|Sun, Jun 30|Delta Air Lines
        AU$418
        AU$418
      • CHS16:00
        6h 49m
        1 stop
        DSM21:49
        Charleston - Des Moines|Fri, Jul 12|United Airlines
        AU$422
        AU$422
      • CHS13:00
        3h 5m
        Direct
        DSM14:00
        Charleston - Des Moines|Mon, Jun 3|American Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Selected Airlines from Charleston International Airport to Des Moines International Airport

See which airlines fly from Charleston to Des Moines. Find the airline that best meets your travel needs by comparing prices and treat yourself to an enjoyable journey.

American Airlines
From AU$316
Delta Air Lines
From AU$386
Southwest Airlines
From AU$388
Breeze Airways
From AU$395
United Airlines
From AU$415
Alaska Airlines
From AU$1,480
ANA airlines

Find more flights and airlines

Flight Schedule from Charleston International Airport to Des Moines International Airport

Check the schedule for flights from Charleston to Des Moines and find the flight that best matches your travel plans.

Flight info.
Departure
Arrival
Weekly Schedule

  1. DL2794

    Delta Air Lines

    05:30

    CHS

    1.2h

    06:40

    ATL

    SMTWTFS
    Search

  2. DL2220

    Delta Air Lines

    09:55

    ATL

    2.2h

    11:05

    DSM

    SMTWTFS

  3. UA2333

    United Airlines

    06:40

    CHS

    2.4h

    08:05

    ORD

    S--WTFS
    Search

  4. UA2099

    United Airlines

    09:03

    ORD

    1.4h

    10:27

    DSM

    -----F-

  5. DL1664

    Delta Air Lines

    08:00

    CHS

    1.2h

    09:10

    ATL

    SMTWTFS
    Search

  6. DL2220

    Delta Air Lines

    09:55

    ATL

    2.2h

    11:05

    DSM

    SMTWTFS

  7. AA1531

    American Airlines

    11:21

    CHS

    1.1h

    12:30

    CLT

    SMTWTFS
    Search

  8. AA2962

    American Airlines

    13:03

    CLT

    2.4h

    14:24

    DSM

    SMTWTFS

  9. UA3419

    United Airlines

    16:05

    CHS

    2.6h

    17:42

    ORD

    SMTWTFS
    Search

  10. UA1576

    United Airlines

    20:20

    ORD

    1.4h

    21:44

    DSM

    SMTWTFS

  11. DL524

    Delta Air Lines

    18:00

    CHS

    1.3h

    19:19

    ATL

    -MT--F-
    Search

  12. DL2306

    Delta Air Lines

    21:09

    ATL

    2.2h

    22:19

    DSM

    SMTWTFS
Find more flights and airlines

Charleston International Airport to Des Moines International Airport Flights Info

Flight distance1,540.44km
Cheapest one-way ticket priceAU$316
Cheapest return ticket priceAU$489

FAQs for Charleston International Airport to Des Moines International Airport Flights

  • Which airline operates the most direct flights from Charleston International Airport (CHS) to Des Moines International Airport (DSM)?

    United Airlines is a very popular airline operating an average of 2 flights per month.

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