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Flights from Santiago to Cusco

Book direct flights from Santiago to Cusco: One way flights from $128, round trip flights from $317. Find flight deals for the next 3 months below.

      • Cheapest nonstop
        SCL 6:10 AM
        3h 30m
        Nonstop
        CUZ 8:40 AM
        Santiago - Cusco | Wed, Aug 5 | LATAM Airlines
        CUZ 9:40 AM
        3h 20m
        Nonstop
        SCL 2:00 PM
        Cusco - Santiago | Sat, Aug 8 | LATAM Airlines
        $317 $352
        10% off
        10% off
        $352 $317
      • SCL 6:10 AM
        4h 30m
        Nonstop
        CUZ 8:40 AM
        Santiago - Cusco | Tue, Sep 8 | LATAM Airlines
        CUZ 9:40 AM
        2h 20m
        Nonstop
        SCL 2:00 PM
        Cusco - Santiago | Thu, Sep 10 | LATAM Airlines
        $328 $352
        7% off
        7% off
        $352 $328
      • SCL 4:50 PM
        7h 35m
        1 stop
        CUZ 11:25 PM
        Santiago - Cusco | Thu, Aug 6 | LATAM Airlines
        CUZ 7:30 AM
        8h 5m
        1 stop
        SCL 4:35 PM
        Cusco - Santiago | Thu, Aug 13 | LATAM Airlines
        $235 $352
        33% off
        33% off
        $352 $235
      • SCL 8:20 PM
        10h 50m
        1 stop
        CUZ 6:10 AM
        Santiago - Cusco | Fri, Aug 28 | Sky Airline
        CUZ 4:30 PM
        10h 46m
        1 stop
        SCL 4:16 AM
        Cusco - Santiago | Wed, Sep 2 | JetSMART Airlines
        $257
        27% off
        $352 $257
      • SCL 4:56 AM
        7h 24m
        1 stop
        CUZ 11:20 AM
        Santiago - Cusco | Fri, Aug 28 | JetSMART Airlines
        CUZ 4:30 PM
        10h 46m
        1 stop
        SCL 4:16 AM
        Cusco - Santiago | Wed, Sep 2 | JetSMART Airlines
        $258
        27% off
        $352 $258
      • SCL 6:10 AM
        3h 30m
        Nonstop
        CUZ 8:40 AM
        Santiago - Cusco | Fri, Aug 28 | LATAM Airlines
        CUZ 4:30 PM
        10h 46m
        1 stop
        SCL 4:16 AM
        Cusco - Santiago | Wed, Sep 2 | JetSMART Airlines
        $301
        14% off
        $352 $301
      • SCL 11:35 AM
        9h 55m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Sat, Aug 1 | Sky Airline
        CUZ 9:10 PM
        7h 25m
        1 stop
        SCL 5:35 AM
        Cusco - Santiago | Sat, Aug 8 | Sky Airline
        $310
        12% off
        $352 $310
      • SCL 4:41 AM
        13h 29m
        1 stop
        CUZ 5:10 PM
        Santiago - Cusco | Tue, Aug 18 | JetSMART Airlines
        CUZ 8:05 PM
        7h 6m
        1 stop
        SCL 4:11 AM
        Cusco - Santiago | Thu, Aug 20 | JetSMART Airlines
        $327
        7% off
        $352 $327
      • SCL 5:00 AM
        16h 30m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Tue, Aug 4 | Sky Airline
        CUZ 6:50 PM
        9h 45m
        1 stop
        SCL 5:35 AM
        Cusco - Santiago | Thu, Aug 6 | Sky Airline
        $329
        7% off
        $352 $329
      • SCL 9:20 PM
        25h 10m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Tue, Sep 8 | Sky Airline
        CUZ 8:30 PM
        8h 5m
        1 stop
        SCL 6:35 AM
        Cusco - Santiago | Thu, Sep 10 | Sky Airline
        $330
        6% off
        $352 $330
      • SCL 1:00 PM
        17h 25m
        1 stop
        CUZ 2:00 PM
        Santiago - Cusco | Sat, Jul 18 | Normal Airline
        CUZ 3:00 PM
        6h
        Nonstop
        SCL 4:00 PM
        Cusco - Santiago | Mon, Jul 20 | Normal Airline
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      • Cheapest nonstop
        SCL 6:10 AM
        3h 30m
        Nonstop
        CUZ 8:40 AM
        Santiago - Cusco | Wed, Aug 26 | LATAM Airlines
        $128 $137
        7% off
        7% off
        $137 $128
      • SCL 12:35 PM
        24h
        1 stop
        CUZ 11:35 AM
        Santiago - Cusco | Sat, Aug 8 | Sky Airline
        $120 $137
        12% off
        12% off
        $137 $120
      • SCL 5:00 AM
        15h 50m
        1 stop
        CUZ 7:50 PM
        Santiago - Cusco | Thu, Aug 20 | Sky Airline
        $125 $137
        9% off
        9% off
        $137 $125
      • SCL 8:20 PM
        16h 5m
        1 stop
        CUZ 11:25 AM
        Santiago - Cusco | Wed, Aug 26 | Sky Airline
        $125
        9% off
        $137 $125
      • SCL 9:20 PM
        25h 10m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Tue, Sep 8 | Sky Airline
        $127
        7% off
        $137 $127
      • SCL 6:00 AM
        16h 30m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Thu, Sep 10 | Sky Airline
        $127
        7% off
        $137 $127
      • SCL 6:00 AM
        16h 30m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Wed, Sep 9 | Sky Airline
        $127
        7% off
        $137 $127
      • SCL 5:00 AM
        16h 45m
        1 stop
        CUZ 8:45 PM
        Santiago - Cusco | Sat, Jul 18 | Sky Airline
        $127
        7% off
        $137 $127
      • SCL 4:41 AM
        13h 29m
        1 stop
        CUZ 5:10 PM
        Santiago - Cusco | Wed, Aug 26 | JetSMART Airlines
        $128
        7% off
        $137 $128
      • SCL 5:00 AM
        16h 30m
        1 stop
        CUZ 8:30 PM
        Santiago - Cusco | Thu, Aug 13 | Sky Airline
        $128
        7% off
        $137 $128
      • SCL 1:00 PM
        17h 25m
        1 stop
        CUZ 2:00 PM
        Santiago - Cusco | Sat, Jul 18 | Normal Airline
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        Find more flights

Find cheap airlines flights from Santiago to Cusco

You can choose from 1 airlines that fly from Santiago to Cusco, including LATAM Airlines, LATAM Airlines has lowest fares on this route.
LATAM Airlines logo LATAM Airlines
Airlines are determined based on actual purchased flight tickets from Santiago to Cusco according to previous 12 months data from Trip.com.

Flight Info | Santiago to Cusco

The distance between Santiago and Cusco is approximately 2,211.1 km. It takes around 4 hours on average to fly from Santiago to Cusco. Based on Trip.com's data travel demand peaks in July. The off-season for travel is November.

Cheapest one-way flight price$120
Cheapest round-trip ticket price$235
Off-season for travelNovember
Peak season for travelJuly
Flight distance2,211.1 km
Average flight time4 hours
Popular airlineLATAM Airlines
Flight statistics for the Santiago–Cusco route are based on aggregated booking data from Trip.com over the past 12 months.

Trip.com price insights on flights from Santiago to Cusco

Which month has the cheapest one-way flights from Santiago to Cusco?

The average price of one-way flights from Santiago to Cusco purchased by Trip.com users by month over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from Santiago to Cusco is July, with an average price of $186; while the month with the highest flight price is usually January, with an average price of up to $291.

$291
$239
$186
$134
  • $186
    Jul
  • $217
    Aug
  • $204
    Sep
  • $203
    Oct
  • $186
    Nov
  • $266
    Dec
  • $291
    Jan
  • $233
    Feb
  • $215
    Mar
  • $216
    Apr
  • $217
    May
  • $248
    Jun

Frequently Asked Questions

  • What are the cheapest flights from Santiago to Cusco (SCL-CUZ)?

    Based on Trip.com data, Sky Airline offers one-way fares as low as $120 on Cheapest nonstop routes (e.g. SCL to CUZ on Sat, Aug 8), while LATAM Airlines offers Cheapest nonstop round-trips from $235 departing on Thu, Aug 6 and returning on Thu, Aug 13.
  • At the moment, you can catch a nonstop flight from Santiago to Cusco with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes around 4 hours to fly from Santiago (SCL) to Cusco (CUZ).
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santiago to Cusco is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 9 flight per week flying from Santiago to Cusco. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: -/-/T/-/T/-/S -- LA2467 (20:32) LATAM Airlines: S/M/T/W/T/F/S -- LA2367 (15:14)
  • To find best deals on flights from Santiago to Cusco, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sat, Aug 8, with one-way flights priced at just $120.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is LATAM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Cusco travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Santiago to Cusco is November, when demand for travel is lower.
  • After crunching the numbers on our July flight calendar, it's currently cheapest to fly from Santiago to Cusco on July 21, 2026 with Sky Airline, with prices starting at $124.
  • You can land at any one of the following hubs in Cusco, with Arturo Merino Benitez International Airport to Alejandro Velasco Astete International Airport (SCL-CUZ) is by far the most common option on this route: Alejandro Velasco Astete International Airport (CUZ).
  • The time difference between Cusco and Santiago is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Explore More Popular Flights

Note: Prices shown on this page are estimated lowest price and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed in this page are all-inclusive prices (incl. taxes, fuel surcharge, civil aviation development fund, etc) with all fees confirmed before payment. Fees for luggage, meals, WLAN, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page were updated within last 24 hours—even in real-time. The more popular the route, the more precise the data.

Change & Cancellation Policy

Trip.com displays flight cancellation and change policies for each flight ticket during the booking process, including fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy.
Cancellation/change due to a flight schedule change:
If the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.