Hotels in Santee

Best Santee Hotels

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13 Best Hotels to Stay in Santee

Trip.com brings you a curated list of top accommodations in Santee, complete with reviews, price insights, and amenity highlights, making it easy to find the perfect place to stay.
Most Booked
Lowest price
Closest to downtown
Highest Rated
Comfort Inn & Suites Santee I-95 Hotels in Santee
Comfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in Santee
57
Hotels in Santee
Private parking
Gym
Wake-up call
+4
Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 1.2 mi (1.9 km) from Santee Town Hall and 1.4 mi (2.2 km) from Santee State Park. Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine. A complimentary buffet breakfast is included. Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite. Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.
Very Good
100 reviews
8.0/10
1 night
From $119
Check availability
Travelodge by Wyndham Santee Hotels in Santee
Travelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in Santee
30
Hotels in Santee
Private parking
Wi-Fi in public areas
Golf course
+2
"Ummmm wrong room given at start Breakfast was pieces of pastry cut up...o.o Coffee was beyond burnt Least it had a room to be safe from the elements"
99 reviews
6.8/10
1 night
From $57
Check availability
Best Western Plus Santee Inn Hotels in Santee
Best Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in Santee
48
Hotels in Santee
Public parking
Gym
Wake-up call
+6
"There is an Asian restaurant across the street. It tastes good. I can enjoy such a comfortable meal in the south. I feel very satisfied. Very close to the lake, just a few minutes drive. The hotel is a standard budget motel!"
Very Good
99 reviews
8.5/10
1 night
From $113
Check availability
Hampton Inn Santee Hotels in Santee
Hampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in Santee
99+
Hotels in Santee
Public parking
Gym
Wi-Fi in public areas
+6
"The breakfast was good and the food was good. The rooms are large and the service is warm. be quiet. There are many restaurants around to eat, which is very convenient. Huanpeng's brand is not bad, the price is moderate, suitable for rest in the middle of the journey."
Amazing
100 reviews
9.4/10
1 night
From $130
Check availability
Holiday Inn SANTEE by IHG Hotels in Santee
Holiday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in Santee
59
Hotels in Santee
Golf course
Gym
Public parking
+5
The Holiday Inn Santee hotel is perfect for recreational activities. Just off I-95 in Santee, SC, our hotel's location is less than an hour from both Columbia and Charleston, two unique cities to visit for a day trip. For those looking for a little relaxation, there is plenty to do in Santee. Our hotel's guests can enjoy the numerous golf courses that dot this area. Visitors also tend to gravitate towards Lake Marion for fishing, as this area is famous for its striped bass and huge catfish. The beautiful lake is supplemented by the glorious, blooming flowers and the clouds of colorful, flitting butterflies that you can find at the Edisto Memorial Gardens. Those on business trips also find it very easy to get things done in Santee, SC. The hotel's proximity to a number of golf courses can provide a peaceful backdrop for intense meetings and business lunches. The 24-hour Business Center and free Internet access are provided to help you make the most of your time. After a day out on the lake or on the golf courses, come back and enjoy some comfort food in the hotel's restaurant. Let the heated pool work for you after a long day of meetings or play. "Southern hospitality" isn't just a slogan for us; it's our guarantee for great, friendly service. Make your reservation today to experience our brand of South Carolina charm!
Very Good
99 reviews
8.0/10
1 night
From $128
Check availability
Baymont by Wyndham Santee Hotels in Santee
Baymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in Santee
53
Hotels in Santee
Public parking
Wake-up call
Wi-Fi in public areas
+3
"We are pleased our stay at Baymont Windham in Santee,SC. Clean room, good service, ideal location next to 95,."
Good
101 reviews
7.6/10
1 night
From $70
Check availability
Tru by Hilton Santee Hotels in Santee
Tru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in Santee
51
Hotels in Santee
Parking
EV charging station
Gym
+3
"Every time I drive back to New York from Florida, I will live here. It is convenient and clean. It also accepts pets. There is no microwave in the room. But there is a front desk downstairs. It is still very recommended."
Very Good
100 reviews
8.8/10
1 night
From $114
Check availability
Fairfield Inn & Suites Santee Hotels in Santee
Fairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in Santee
34
Hotels in Santee
Private parking
Gym
Wi-Fi in public areas
+8
"I was extremely pleased with my overnight stay. As a Marriott Owner/Member, I try to find the perfect place to stay with my two small dogs. Dog owners are at a terrible disadvantage when finding a clean, safe hotel to stay. The Fairfield provided everything. The wonderful people at the front desk were so welcoming, the breakfast was delicious with many choices, and the carpets were spotless; you would never know animals were there. The outside grounds were clean and free from any animal deposits or human trash and beautiful flowers and trimmed landscaping was so pretty. In addition, guests were given welcome gift bags with bottled water and cookies. I will certainly be back!"
Amazing
107 reviews
9.7/10
1 night
From $145
Check availability
Red Roof Inn Santee Hotels in Santee
Red Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in Santee
47
Hotels in Santee
Private parking
Wake-up call
Fax/copying service
Red Roof Inn Santee offers a budget-friendly stay in the heart of "America's Value Golf Destination." Whether you're here for championship golf, lake recreation, or exploring the area, Red Roof Inn Santee provides dependable comfort and value in beautiful Santee, South Carolina. Red Roof Inn Santee is a welcoming and affordable choice for golf enthusiasts and families seeking relaxation near Lake Marion. With friendly service and thoughtful amenities, we make every stay simple and enjoyable. Guests can expect a pleasant stay with essentials, including free Wi-Fi, a free expanded cable package featuring HBO, a complimentary continental breakfast, and coffee in the lobby. Each room also features a microwave and mini-refrigerator for added convenience. We are proud to be a pet-friendly hotel, so your four-legged companion is always welcome. Our Santee, SC hotel is located near popular attractions such as Lake Marion Golf Course, Santee Cooper Country Club, Lake Marion, Santee State Park, the Santee National Wildlife Refuge, and the Santee Conference Center, all within easy reach.
89 reviews
6.4/10
1 night
From $59
Check availability
Quality Inn & Suites Hotels in Santee
Quality Inn & Suites Hotels in SanteeQuality Inn & Suites Hotels in SanteeQuality Inn & Suites Hotels in SanteeQuality Inn & Suites Hotels in SanteeQuality Inn & Suites Hotels in SanteeQuality Inn & Suites Hotels in Santee
86
Hotels in Santee
Private parking
Wi-Fi in public areas
Golf course
+6
Located in Santee, Quality Inn & Suites Santee I-95 is within a 15-minute walk of Santee Cooper Country Club and Santee State Park. This hotel is 1.1 mi (1.7 km) from Santee National Golf Club and 1.4 mi (2.2 km) from Lake Marion. Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless internet access and a fireplace in the lobby. Additional features at this hotel include a banquet hall and a vending machine. Grab a bite to eat at one of the hotel's many dining establishments, which include 7 restaurants and a coffee shop/cafe. Quench your thirst with your favorite drink at the bar/lounge. A complimentary full breakfast is served daily from 6:30 AM to 9:30 AM. Featured amenities include a computer station, a 24-hour front desk, and multilingual staff. Free self parking is available onsite. Make yourself at home in one of the 106 air-conditioned rooms featuring LED televisions. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
97 reviews
6.0/10
1 night
From $64
Check availability
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Trip.com's insights for hotels in Santee

Plan smarter with Trip.com’s data-backed insights on travel seasons so that you can book your Santee hotel at the right time!

Which month offers the lowest hotel rates in Santee?

September is the most affordable month to book a hotel in Santee, with average nightly rates around $106. Prices peak in March, when rates reach about $169 per night.
(Based on Trip.com data from April 11, 2025 to April 11, 2026.)
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Mar

What is the cheapest day of the week for hotels in Santee?

Hotel rates in Santee are typically lowest on Thursday, with average nightly rates around $116. Monday tends to be the most expensive, averaging $149 per night.
(Based on Trip.com data from April 11, 2025 to April 11, 2026.)
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Find your unique stays in Santee

Immerse yourself in the vibrant atmosphere of Santee with our handpicked accommodation options

Most-booked Santee hotels

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Check out these top-booked hotels from the past 30 days!
Ramada by Wyndham Santee I-95 Hotels in Santee
6.3/10
45 review

Ramada by Wyndham Santee I-95

Hotel near Santee
A popular choice among guests booking hotels in Santee
Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.
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Super 8 by Wyndham Santee Hotels in Santee
6.7/10
62 review

Super 8 by Wyndham Santee

Hotel near Santee
A popular choice among guests booking hotels in Santee
Make our Super 8 Santee hotel your home base for golf and recreation in South Carolina. Located off I-95 halfway between New York City and Miami our hotel is a comfortable stopping point on your East Coast road trip.
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Econo Lodge Hotels in Santee
6.3/10
17 review

Econo Lodge

Hotel near Santee
A popular choice among guests booking hotels in Santee
A stay at Econo Lodge Santee places you in the heart of Santee, just a 4-minute walk from Santee Cooper Country Club and within a 5-minute drive of Santee National Golf Club. This hotel is 1.4 mi (2.2 km) from Santee State Park and 2 mi (3.2 km) from Santee Town Hall. Take in the views from a garden and make use of amenities such as complimentary wireless internet access and barbecue grills. Featured amenities include a 24-hour front desk and luggage storage. Free self parking is available onsite. Make yourself at home in one of the 37 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and microwaves, as well as phones with free local calls.
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FAQs About Santee Hotels

Which hotels are the best hotels to stay at in Santee?

Santee has many popular hotels. Whether you're looking for a business stay or a vacation hotel, Fairfield Inn & Suites Santee (from $140), Tru by Hilton Santee (from $127) and Travelodge by Wyndham Santee (from $43) are best choices.

What are the best pet-friendly hotels in Santee?

Tru by Hilton Santee (from $127) is pet-friendly. Take your pets with you during traveling.

What hotels in Santee provide swimming pools?

Fairfield Inn & Suites Santee (from $140), Tru by Hilton Santee (from $127) and Best Western Plus Santee Inn (from $121) are hotels with swimming pools. Book now and enjoy your swimming pool!

Which hotels in Santee have the best breakfast?

Holiday Inn SANTEE by IHG (from $131),Fairfield Inn & Suites Santee (from $140) and Tru by Hilton Santee (from $127) offer high-quality breakfast. Enjoy your wonderful journey with delicious breakfast!

What hotel deals are available in Santee?

Trip.com offers multiple promotions and discounts all year round for both new users and loyal customers . Please check the promotions page to see what promotions are available now on Trip.com.

Santee Hotels Info

Number of reviews
1,116
Total properties
13
Weekday Avg. Price
$120
Weekend Avg. Price
$144
Trending hotel
Fairfield Inn & Suites Santee